2-Fluoro-3-nitrobenzoic Acid CAS 317-46-4 Manufacturer & Bulk Supplier | Zhishang Bio
2-Fluoro-3-nitrobenzoic Acid
- Surfactant Appearance: powder
- Proportion: Minimum 99.0%
- Inventory: In stock
- Sample: In stock
- Zhishang Chemical: Supplier and manufacturer of 2-Fluoro-3-nitrobenzoic Acid
Basic Info of 2-Fluoro-3-nitrobenzoic Acid
| 2-Fluoro-3-nitrobenzoic acid Chemical Properties |
| Melting point | 138 – 140°C |
| Boiling point | 347.6±27.0 °C(Predicted) |
| density | 1.568±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| pka | 2.32±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Air Sensitive |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C7H4FNO4/c8-6-4(7(10)11)2-1-3-5(6)9(12)13/h1-3H,(H,10,11) |
What is 2-Fluoro-3-nitrobenzoic Acid？
2-Fluoro-3-nitrobenzoic acid (CAS 317-46-4) is an essential fluorinated aromatic intermediate widely used in medicinal chemistry, drug synthesis (such as BRAF inhibitors like Dabrafenib), agrochemicals, and fine chemical applications.
Chemical Reactivity & Synthesis Applications
Nucleophilic Aromatic Substitution
Due to the strong electron-withdrawing nature of both the nitro group and the carboxyl group in the ortho/para positions relative to the fluorine atom, the C-2 fluorine acts as an effective leaving group. It readily undergoes nucleophilic displacement with amines, alkoxides, or thiols to construct functionalized aromatic scaffolds.
Pharmaceutical Intermediate
Oncology: Acts as a key starting raw material for kinase inhibitors, including the BRAF inhibitor Dabrafenib.
General Derivatives: Serves as a building block for benzenesulfonamide thiazoles, quinolone derivatives, and cysteine protease inhibitors.
Carboxylic Acid Transformations
The -COOH functional group can undergo standard derivatizations, such as conversion to acyl chlorides via oxalyl chloride/thionyl chloride, or esterification and amide coupling reactions using standard coupling reagents (e.g., EDC, HATU).
Product Packaging
If you want to buy 2-Fluoro-3-nitrobenzoic Acid, pls contact us to get a free quote.
Superior 2-Fluoro-3-nitrobenzoic Acid Series | Reliable Quality & Sufficient Supply
Why choose Zhishang Bio?
1. Manufacturing and R&D capabilities (Experience&Expertise)
Large scale production and agile response: With first-class manufacturing and research and development bases, we serve over 6000 factories and procurement customers worldwide.
High cost-effectiveness and supply resilience: Relying on China’s complete and strong chemical industry chain, through independent route optimization, we aim to reduce the average comprehensive procurement cost of overseas customers by 15% to 25%.
Full cycle support from R&D to commercial: supporting Gram scale laboratory research and development, Kg scale pilot testing, and Tonnage commercial bulk supply.
2. Technology and Quality Control Barrier (Authority&Trust)
Precise quality inspection system: equipped with professional laboratories and a complete quality control (QA/QC) team, equipped with analytical instruments such as HPLC, GC, NMR, MS, etc., achieving “one inspection per batch, traceable batch by batch”.
Fine control of impurities and isomers: For Regioisomers and trace impurities such as defluorination/denitrification, the control standards are much higher than the industry average.
Compliance and foreign trade guarantee: Provide a complete set of compliance documents (COA, SDS, TDS, NMR/HPLC spectra), familiar with the global dangerous/non dangerous goods customs declaration process and international logistics standards.
2-Fluoro-3-nitrobenzoic Acid Supply Plan & Delivery Schedule
A reliable 2-Fluoro-3-nitrobenzoic Acid supplier should be able to explain what happens after a purchase inquiry. Our standard B2B workflow is designed to keep the process clear from specification review through shipment.
Inquiry → Specification Confirmation → COA/Sample Review → Order Confirmation → Stock Allocation or Production → QC Inspection → Packing → Shipment
For sample or small-volume orders, availability can normally be checked against current inventory. Larger 2-Fluoro-3-nitrobenzoic Acid bulk orders may require production scheduling, particularly when the requested quantity exceeds available warehouse stock.
| Parameter | Standard Order | Bulk Wholesale Order | Urgent Order |
|---|---|---|---|
| Minimum Order Quantity (MOQ) | 1 kg | Upon negotiation | 1 kg |
| Supply Volume | Stable supply | Up to 50 tons per month | Permanent stock: 20‑30 tons |
| Lead Time | 3‑7 working days | 7‑20 working days | Shipment within 24‑48 hours |
| Payment Terms | T/T, L/C, Western Union | T/T, L/C | T/T preferred |
| Price Policy | Standard price | Support long‑term contracts & price lock | Confirmed according to stock availability |
| Service Features | For regular purchases | For long‑term & large‑volume purchases | Quick response & urgent delivery |
FAQ
Every commercial shipment of 2-Fluoro-3-nitrobenzoic acid (CAS 317-46-4) is accompanied by a batch-specific Certificate of Analysis (COA), Safety Data Sheet (SDS), and Technical Data Sheet (TDS). For customer process validation, pilot scale scaling, or regulatory filing support, we provide high-resolution analytical documentation including:
HPLC Purity Profile (Standard 98.0%, custom batches up to 99.5%).
Residual Solvents Analysis via Headspace GC (ensuring compliance with ICH Q3C guidelines).
Loss on Drying (LOD) and elemental analysis.
In 2-Fluoro-3-nitrobenzoic acid, the fluorine atom at the C-2 position is strongly activated toward nucleophilic aromatic substitution due to the synergistic electron-withdrawing effects of both the neighboring nitro group at C-3 and the carboxylic acid group at C-1.
Storage Stability: The raw material is hygroscopic and sensitive to ambient air moisture over extended periods. We package it in sealed, moisture-proof aluminum foil bags with desiccant or PE-lined drums, recommended to be stored at 2-8℃in a dark, dry warehouse to prevent slow hydrolysis.
Synthesis Reaction Control: When executing coupling or reduction reactions, temperature and base choice are crucial. For selective reduction of the nitro group to synthesize 3-amino-2-fluorobenzoic acid, catalyst selection and hydrogen pressure must be precisely optimized to avoid unwanted catalytic hydrodefluorination.
Under global transport regulations (DOT, IATA, IMDG), 2-Fluoro-3-nitrobenzoic acid (CAS 317-46-4) is generally classified as a non-dangerous/general chemical product (GHS Category 07: Warning for skin/eye irritation, H315/H319/H335), which significantly reduces shipping complexity and freight surcharges compared to restricted hazardous substances.
R&D & Lab Scale: Packed in 100g,500g,1kg double-sealed moisture-proof aluminum foil bags with heat-shrink tamper-evident seals.
Commercial / Bulk Scale: 25 kgfiber drums with inner dual-layer heavy-duty polyethylene (PE) bags.
Custom Logistics: All exports are supplied with complete HS Code documentation (HS: 2916399090) and SDS for smooth customs clearance worldwide via DHL/FedEx Express, air freight, or ocean shipping.
Yes. Shandong Zhishang Bio provides custom processing and Contract Manufacturing (CMO/CDMO) starting from CAS 317-46-4:
Particle Size Customization: We can perform controlled micronization or sieve classification if your synthesis pathway requires a specific particle size distribution for fast dissolution rates.
Downstream Derivatization: If your production process requires pre-converted intermediates—such as 2-fluoro-3-nitrobenzoyl chloride (via thionyl chloride conversion), methyl 2-fluoro-3-nitrobenzoate, or specific amide couplings—our synthetic R&D laboratory can manufacture these downstream building blocks under strict NDA to help streamline your in-house synthesis chain.
References
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2-Fluoro-3-nitrobenzoic Acid Supplier and Manufacturer
As a 2-Fluoro-3-nitrobenzoic Acid supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best 2-Fluoro-3-nitrobenzoic Acid raw materials to customers all over the world.
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