2-Methoxyethyl Chloride | Versatile Alkylating Agent for Organic Synthesis
Product Concept
2-Methoxyethyl Chloride (CAS 627-42-9) is a highly reactive alkyl halide compound featuring a unique combination of ether and chloroalkyl functional groups. This bifunctional molecule serves as a critical building block in organic synthesis, offering dual reactivity for nucleophilic substitution and ether formation. With its molecular formula C₃H₇ClO and molecular weight of 94.54 g/mol, this clear, colorless liquid demonstrates excellent solubility in common organic solvents (e.g., ethanol, acetone) while maintaining moderate water solubility (≈50 g/L at 20°C). Its balanced lipophilicity (logP = 0.89) and low viscosity make it an ideal reagent for both laboratory-scale and industrial applications.
Technical Specifications
- Molecular Formula: C₃H₇ClO
- Molecular Weight: 94.54 g/mol
- Appearance: Clear, colorless liquid
- Purity: ≥99% (GC)
- Boiling Point: 94-96°C
- Density: 1.052 g/cm³ at 20°C
- Refractive Index: n²⁰D = 1.417
- Storage: 2-8°C under nitrogen atmosphere
Chemical Reactivity
- Nucleophilic Substitution: Reacts with amines, alcohols, and thiols
- Grignard Formation: Forms stable Grignard reagents
- Ether Cleavage: Susceptible to strong acid-mediated cleavage
- Radical Reactions: Participates in free radical polymerization
Industrial & Research Applications
Pharmaceutical Synthesis
- Intermediate for β-blocker production
- Building block for antiviral agents
- Precursor for local anesthetics
Polymer Chemistry
- Monomer for functional polyethers
- Crosslinking agent for epoxy resins
- Modifier for polyurethane foams
Organic Synthesis
- Alkylating agent for heterocycles
- Etherification reagent
- Starting material for crown ethers
Synthetic Routes
- Chlorination of 2-methoxyethanol with thionyl chloride
- Catalytic hydrochlorination of ethylene oxide
- Methylation of 2-chloroethanol
Quality Assurance
- Purity Analysis: GC-FID (HP-5 column)
- Moisture Content: Karl Fischer titration (<100 ppm)
- Impurity Profile: GC-MS identification
- Stability Testing: Accelerated aging studies
Safety & Handling
- Flash Point: 12°C (Tag Closed Cup)
- Autoignition Temperature: 245°C
- GHS Classification: Flammable Liquid Category 2
- Personal Protection: Chemical goggles, nitrile gloves
- Spill Management: Absorb with inert material
