2-Methyl-4-(1,1,1,2,3,3,3-heptafluoro-2-propyl) aniline CAS 238098-26-5

2-Methyl-4-(1,1,1,2,3,3,3-heptafluoro-2-propyl) Aniline (CAS 238098-26-5): Advanced Fluorinated Aromatic Amine

Structural Overview and Key Characteristics

2-Methyl-4-(1,1,1,2,3,3,3-heptafluoro-2-propyl) aniline (CAS 238098-26-5) represents a sophisticated fluorinated aromatic amine compound with the molecular formula C10H8F7N. This specialty chemical features a unique combination of electron-withdrawing heptafluoropropyl groups and an electron-donating amino group, creating exceptional electronic asymmetry that makes it particularly valuable in advanced material science. The crystalline solid demonstrates remarkable thermal stability (decomposition point >250°C) and chemical inertness, while maintaining solubility in common organic solvents like dichloromethane and THF…

Physicochemical Properties

Molecular Weight: 287.17 g/mol
Boiling Point: 198-202°C at 760 mmHg
Density: 1.62 g/cm³ at 25°C
Flash Point: 112°C (closed cup)

Industrial Applications

Pharmaceutical Synthesis

• Critical intermediate for kinase inhibitor development
• Building block in PET tracer molecules
• Chiral resolution agent for enantiomer separation

Advanced Material Development

• Monomer for fluorinated polyimide production
• Surface modification agent for hydrophobic coatings
• Liquid crystal alignment layer component

Agrochemical Formulations

• Key precursor for novel fluorinated pesticides
• UV-stabilizing additive in crop protection agents
• Soil persistence modifier development

Synthetic Methodology

Step 1: Fluorination of 2-methyl-4-isopropenylaniline using C3F7I under radical initiation…
Step 2: Catalytic hydrogenation with Pd/C catalyst at 80°C…
Purification: Multi-stage crystallization using hexane/ethyl acetate gradient…

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