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4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone, CAS 446292-07-5 supplier
Description
4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone (CAS 446292-07-5), a chiral aromatic block carrying the molecular formula C₂₁H₂₁N₃O₅ and a mass of 395.41, operates as an indispensable synthetic precursor and regulatory reference standard within the anti-thrombotic drug sector. Formulation chemists track this highly refined molecule primarily for its stereochemical precision, driving core reaction steps for the commercial synthesis of Rivaroxaban—a direct Factor Xa inhibitor. The compound features a unique (2R)-hydroxy-3-phthalimidopropylamine side chain anchored to a para-substituted morpholinone phenyl ring system, where the phthalimide cluster serves as a highly resilient chemical protecting group. This crystalline white solid clears perfectly into liquid vehicles like DMSO, methanol, and chloroform within your laboratory blending tanks, showing a sharp melting threshold between 208°C and 211°C.
The Chiral Synthesis and API Coupling Loop
[Chiral Epoxide Feedstock] + [Morpholinone Phenyl Amine] ➔ [Regiospecific Ring Opening] ➔ [Pure CAS 446292-07-5] ➔ [Desprotection & Oxazolidinone Cyclization] ➔ [Active Rivaroxaban API]
The reaction layout mapped above details how this building block integrates into modern drug manufacturing rows. To safeguard your structural activity relationship (SAR) data, our refining lines enforce the following rigid parameters:
| Analytical Parameter | Checked Value Profile | Operational Benefit |
|---|---|---|
| Active Enantiomeric Purity | 95.00%–98.00% (validated by HPLC) | Prevents optical rotation anomalies |
| Melting Range Consistency | 208.0–211.0°C | Guarantees crystal matrix integrity |
| Solubility (in DMSO/Methanol) | Clear, particulate-free liquid | Eliminates downstream processing filtration |
Product Images & Packaging
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4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone Parameters
| 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Chemical Properties |
| Melting point | 208-211°C |
| Boiling point | 734.9±60.0 °C(Predicted) |
| density | 1.421 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 13.91±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 37mg/L at 20℃ |
| Major Application | pharmaceutical small molecule |
| InChI | InChI=1S/C21H21N3O5/c25-16(12-24-20(27)17-3-1-2-4-18(17)21(24)28)11-22-14-5-7-15(8-6-14)23-9-10-29-13-19(23)26/h1-8,16,22,25H,9-13H2/t16-/m1/s1 |
| InChIKey | CKFVSMPWXAASIQ-MRXNPFEDSA-N |
The application of 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
1. Robust Reference Standard Stock & Scalable Batches
We shield your validation timelines from sudden market shortages by maintaining a constant, multi-tier stock buffer at our central fulfillment depot. Our synthesis assets operate continuous chiral fractionating columns that support everything from micro milligram lots for method validation to massive multi-kilogram freight campaigns for commercial scale-ups. This flexible asset grid ensures you bypass typical manufacturing bottlenecks and raw material shocks. Whether your current analytical run requires a 10mg validation vial or a full commercial lot drop, your cargo clears our transit dock within 48 hours.
2. Airtight AMV Documentation & Quality Validation
Our quality assurance division backs every single container leaving our loading dock with a comprehensive, lot-specific technical dossier, including an official Certificate of Analysis (COA) and a detailed MSDS profile. We monitor every production run via high-performance liquid chromatography (HPLC) to lock down active purity baselines between 95% and 98%, completely eliminating unexpected background noise inside your testing cuvettes. Our in-house application engineers understand exactly how this morpholinone compound tracks as a Phthalimido Descarbonyl Impurity (R-Isomer), directly assisting your lab during regulatory ANDA filing and vendor onboarding.
4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone 's Procurement Guide
Procurement Guidelines
1. Sample Policy
We can provide a 2-3g free trial package (shipping fee required)
2. Batch procurement
Packaging: 25kg/bag; 220kg/barrel; Special packaging according to your needs
MOQ：1kg
3. Customized services
Concentration customization (90% -99%)
Paeonol’s outsourcing services
FAQ
It comes down to stereochemical tracking inside your quality control loops. During active manufacturing campaigns, CAS 446292-07-5 serves as the direct synthetic building block that transforms into the final oxazolidinone ring of Rivaroxaban. However, during downstream high-performance liquid chromatography (HPLC) assays, any unreacted material or inverted R-enantiomer manifests as the Phthalimido Descarbonyl Impurity. Therefore, laboratories utilize this highly refined fraction as a benchmark reference standard to calibrate their analytical methods and map precise degradation curves.
This chiral amine derivative is highly sensitive to moisture uptake, atmospheric oxidation, and direct UV light exposure. Contact with warm air over time can trigger trace hydrolysis of the phthalimide protecting group, creating unexpected side-peaks that ruin your analytical method validation (AMV). To preserve its chemical matrix, warehouse managers must store the solid powder under 2–8°C (35.6–46.4°F) refrigeration inside hermetically sealed containers completely protected from light.
Our high-purity lots are strictly restricted and engineered for laboratory research, analytical method development, forensic profiling, and quality controlled (QC) testing environments. It serves as an essential reference element during commercial batch release validations and ANDA documentation filings to verify enantiomeric thresholds. It is not intended for direct human or veterinary therapeutic administration.
We support multiple procurement tracks tailored to your specific project phase: our standard catalog inventory spans micro-packs of 10 mg, 50 mg, and 100 mg to accommodate initial laboratory screening and structure-activity relationship (SAR) testing. Ready stock configurations are dispatched under temperature-controlled packaging within 1 to 2 business days. For major commercial tonnage contracts or custom packaging configurations, please allow 5 to 7 business days for manufacturing scheduling and quality clearance.
Related References
Manufacturer of 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
Achievements
Advantage
Service
FAQ
Advice on Shipping
Achievements
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Advantage
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Service
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.
