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4-Dimethylaminobenzaldehyde

Zhishang Bio 4-Dimethylaminobenzaldehyde CAS 100-10-7

CAS:100-10-7 | C9H11NO |MW:149.19 | EINECS NO:202-819-0

Payment: L/C,T/T,D/P,Paypal,Money Gram,Western Union

Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP

Transporta: Ocean, Land,Air, DHL,TNT

Port: Shanghai Port, Qingdao Port

Description

4-Dimethylaminobenzaldehyde is an important organic aromatic aldehyde compound with the molecular formula C9H11NO. At room temperature it appears as a yellow-to-light yellow powder or flake with an aromatic smell similar to that of benzaldehyde. 4-Dimethylaminobenzaldehyde is derived from the parent nucleus structure of benzaldehyde, in which one hydrogen atom is replaced by dimethylamino at the para position of the aldehyde group, forming a typical molecular system in which the electron donating group is conjugated with the aldehyde group. Its structural features make it a powerful chemical and photophysical reaction. In terms of physicochemical properties, 4-Dimethylaminobenzaldehyde is slightly soluble in water, but easily soluble in common organic solvents such as ethanol, ether, chloroform, etc. Under certain conditions, the solution may exhibit fluorescence. The presence of electron-donating groups in para positions causes the aldehyde to have a different chemical activity compared to benzaldehyde that is not substituted. This results in a difference in reaction rates and selectivity of nucleophilic reactions. In addition, 4-Dimethylaminobenzaldehyde is sensitive to air and light, and long-term exposure may cause color darkening or decomposition. It is therefore necessary to store the product in a sealed dark environment. From the perspective of chemical synthesis, 4-Dimethylaminobenzaldehyde is usually prepared from N, N-dimethylaniline as the starting material through formylation reaction, and is a key intermediate for the preparation of various fine chemicals in the laboratory and industry. Its unique electronic configuration and functional group combination makes it an important structural unit or chromophore in organic synthesis.

Product Images & Packaging

4-Dimethylaminobenzaldehyde
4-Dimethylaminobenzaldehyde
4-Dimethylaminobenzaldehyde

Product Parameters

4-Dimethylaminobenzaldehyde Chemical Properties
Melting point 72-75 °C(lit.)
Boiling point 176-177 °C (17 mmHg)
bulk density350kg/m3
density 1.10 g/mL at 20 °C
vapor pressure <0.1 hPa (20 °C)
refractive index n20/D 1.417
Fp 164 °C
storage temp. 2-8°C
solubility alcohol: passes test (APHA ≤60)
pkapK1:1.647(+1) (25°C)
form Liquid
color White to pale yellow
OdorCharacteristic odor
Water Solubility 0.3 g/L (20 ºC)
λmax385 nm

The application of 4-Dimethylaminobenzaldehyde

1. Chromogenic agents used in analytical chemistry

This is the most classic and widely used application of 4-Dimethylaminobenzaldehyde. The core principle is that 4-Dimethylaminobenzaldehyde can undergo characteristic condensation reactions with compounds containing primary or secondary amine groups under acidic conditions, generating colored Schiff bases, typically blue to blue purple in color. This response is highly sensitive and specific.

The core component of Ehrlich reagent, 4-Dimethylaminobenzaldehyde, is the main component of the famous Ehrlich reagent. This reagent, which is used in drug testing and for forensic medicine to screen hallucinogens like LSD and Psilocybin quickly on-site, is vital. They are effective because they contain indole ring substances that produce a purple color when contacted with Ehrlich reagents.

In clinical biochemical testing, 4-Dimethylaminobenzaldehyde is a key reagent for measuring urea nitrogen concentration in blood or urine using urease method. Urea is broken down by urease into ammonia. Ammonia reacts with hypochlorous acids and phenols to form indophenol. In early or some improved methods, 4-Dimethylaminobenzaldehyde was directly used for coloring with urea derivatives.

It can be used to colorimetrically determine specific amino acids. The determination of hydroxyproline, in particular, is important for diagnosing fibrotic disorders or abnormal bone metabolism. It is also used to detect biogenic amines, such as tyramine and histamine.

For example, after chromatography of aflatoxin B1, 4-Dimethylaminobenzadehyde spray color can be used for thin layer chromatographic analysis.

2. Key intermediates for organic synthesis, dye industry

4-Dimethylaminobenzaldehyde is an important precursor for the synthesis of a series of triarylmethane dyes and acridine dyes. Condensing various aromatic amines can produce derivatives of cationic colors such as crystal violet and basic fuchsin, which are used widely in textile dyeing, leather dyeing, paper dyeing and biological dyeing. The vivid color originates from the characteristic of 4-Dimethylaminobenzaldehyde itself as a strong electron donating chromophore.

3. Biotechnology and drug development: Auxiliary Tools

In molecular biology, 4-Dimethylaminobenzaldehyde is one of the components of Dische reagent, used for specific identification of deoxyribose in DNA.

In the presence of strong acid, deoxyribose in DNA reacts with 4-Dimethylaminobenzaldehyde to produce a bright blue purple compound, while ribose in RNA does not produce this color or has a different color, which can be used for quantitative determination of DNA content or differentiation between DNA and RNA.

In the pharmaceutical industry, 4-Dimethylaminobenzaldehyde is introduced as a structural unit into more complex drug molecular frameworks. It is used as a starting material or intermediate in the synthesis for certain antimalarial, antiparasitic, and biologically-active indole, quinoline, and other compounds. Aldehydes undergo a variety of reactions, such as condensation, reduction, and cyclization, to create heterocyclic systems.

4-Dimethylaminobenzaldehyde 's Procurement Guide

Procurement Guidelines
1. Sample Policy
We can provide a 2-3g free trial package (shipping fee required)

2. Batch procurement
Packaging: 25kg/bag; 220kg/barrel; Special packaging according to your needs
MOQ:1kg

3. Customized services
Concentration customization (90% -99%)
Paeonol’s outsourcing services

Paeonol

FAQ

Yes, we have our own factory called ” ZhiShang Industry Group “

Yes, we have GMP certificate for some products, and we can provide DMF as well.

 -Quality you require, eg. Assay, Purity, or single impurity

-Quantity you need

-Standard you want, such as USP, EP, JP etc.

Escrow and T/T in advance are highly recommended. We can accept Western Union, Money Gram and Paypal as well.

For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment. 

For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 day.

Manufacturer of 4-Dimethylaminobenzaldehyde

Company Info

Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
 
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
 
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.

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