6-Fluoronicotinic Acid (CAS 403-45-2) - High Purity Intermediate | Zhishang Bio
6-Fluoronicotinic Acid (CAS 403-45-2)
- Surfactant Appearance: powder
- Proportion: Minimum 99.0%
- Inventory: In stock
- Sample: In stock
- Zhishang Chemical: Supplier and manufacturer of 6-Fluoronicotinic Acid
Basic Info of 6-Fluoronicotinic Acid
| Parameter | Specification / Data |
|---|---|
| Chemical Name | 6-Fluoronicotinic Acid / 6-Fluoropyridine-3-carboxylic acid |
| CAS Registry Number | 403-45-2 |
| Molecular Formula | C₆H₄FNO₂ |
| Molecular Weight | 141.10 g/mol |
| Appearance | White to off-white crystalline powder |
| Assay / Purity (HPLC) | ≥ 98.0% (Custom high purity ≥ 99.0% available) |
| Melting Point | 144 ℃ – 148 ℃ |
| Solubility | Soluble in DMF, DMSO and warm methanol; sparingly soluble in water |
| InChI Key | WVZFYQWQUSWZAP-UHFFFAOYSA-N |
| Storage Conditions | Store in a cool, dry, well-ventilated area (2–8 ℃ recommended for long-term stability); keep container tightly sealed |
What is 6-Fluoronicotinic Acid?
6-Fluoronicotinic acid (CAS 403-45-2), also recognized as 6-fluoropyridine-3-carboxylic acid, serves as a vital fluorinated aromatic building block in contemporary organic synthesis and pharmaceutical R&D. Featuring a electron-deficient pyridine ring substituted with both a fluorine atom at the C-6 position and a carboxylic acid functional group at C-3, this molecule offers unique electronic properties and steric features.
The introduction of the fluorine atom significantly alters the pKa, lipophilicity, and metabolic stability of target active molecules. Consequently, medicinal chemists extensively utilize 6-Fluoronicotinic acid as an essential intermediate for drug discovery, crop protection compounds, and specialized biochemical tools.
Key Applications of 6-Fluoronicotinic acid
3.1 Heterocyclic Pharmaceutical Intermediates
6-Fluoronicotinic acid plays a central role in constructing biologically active compounds. The electrophilic C-6 halogen position readily undergoes nucleophilic aromatic substitution reactions with amines, alkoxides, and thiols. This reaction path allows quick access to 6-functionalized nicotinic derivatives, which act as pharmacophores in targeted kinase inhibitors, antibacterial agents, and central nervous system (CNS) modulators.
3.2 Amide Coupling & Derivatization
The carboxylic acid motif at the 3-position provides a versatile handle for peptide coupling reagents to form functionalized 6-fluoronicotinamides. These derivatives are widely screened for enzyme inhibition profiles and receptor selectivity.
3.3 Fluorinated Agricultural Chemistry
Beyond human health applications, the fluorinated pyridine core is increasingly adopted in agrochemical innovation. Inserting the 6-fluoropyridinyl group enhances photo-stability and systemic mobility within plant tissues, leading to potent, low-dosage herbicides and fungicides.
Product Packaging
If you want to buy 6-Fluoronicotinic Acid, pls contact us to get a free quote.
Superior 6-Fluoronicotinic Acid Series | Reliable Quality & Sufficient Supply
Commercial Advantages of Partnering with Zhishang Bio
Consistent Batch-to-Batch Quality:
Our dedicated QA team conducts strict raw material qualification and in-process controls (IPC), eliminating batch variations and ensuring seamless scale-up for your project.
Complete Analytical Support:
We provide comprehensive documentation alongside every order, including Certificates of Analysis (COA), High-Performance Liquid Chromatography (HPLC) traces, and Nuclear Magnetic Resonance (NMR) spectra.
Flexible Scale Operations:
Whether your research team requires grams for milligram-scale assay testing or metric tons for pilot plant production, our flexible manufacturing capacity adjusts to your timeline.
Transparent Supply Chain & Technical Assistance:
Our technical team brings years of synthetic chemistry expertise to help solve challenges related to solubility, storage, or derivative processing.
6-Fluoronicotinic Acid Supply Plan & Delivery Schedule
A reliable 6-Fluoronicotinic Acid supplier should be able to explain what happens after a purchase inquiry. Our standard B2B workflow is designed to keep the process clear from specification review through shipment.
Inquiry → Specification Confirmation → COA/Sample Review → Order Confirmation → Stock Allocation or Production → QC Inspection → Packing → Shipment
For sample or small-volume orders, availability can normally be checked against current inventory. Larger 6-Fluoronicotinic Acid bulk orders may require production scheduling, particularly when the requested quantity exceeds available warehouse stock.
| Parameter | Standard Order | Bulk Wholesale Order | Urgent Order |
|---|---|---|---|
| Minimum Order Quantity (MOQ) | 1 kg | Upon negotiation | 1 kg |
| Supply Volume | Stable supply | Up to 50 tons per month | Permanent stock: 20‑30 tons |
| Lead Time | 3‑7 working days | 7‑20 working days | Shipment within 24‑48 hours |
| Payment Terms | T/T, L/C, Western Union | T/T, L/C | T/T preferred |
| Price Policy | Standard price | Support long‑term contracts & price lock | Confirmed according to stock availability |
| Service Features | For regular purchases | For long‑term & large‑volume purchases | Quick response & urgent delivery |
FAQ
Every dispatch includes a comprehensive Certificate of Analysis (COA) reflecting lot-specific assay, melting point, and moisture content. For qualified enterprise accounts or R&D partners, we also provide raw HPLC chromatograms and 1H-NMR spectrum data upon request prior to shipment.
The fluorine substituent at position 6 is activated by the electron-withdrawing nature of both the pyridine nitrogen and the 3-carboxylic group. Heating with primary or secondary aliphatic amines in polar aprotic solvents (such as DMF or acetonitrile) in the presence of a mild base generally yields the 6-aminonicotinic acid derivative cleanly without requiring transition-metal catalysts.
6-Fluoronicotinic acid should be handled inside a certified fume hood by trained personnel wearing standard protective equipment (gloves, safety goggles, lab coat). Avoid dust generation and inhalation. Detailed safe handling instructions are available in our Safety Data Sheet (SDS).
Yes. Zhishang Bio offers contract synthesis and custom manufacturing services. If your process requires esterification, amide formation, or pre-transformed 6-substituted pyridine intermediates based on CAS 403-45-2, our R&D team can develop custom synthetic routes tailored to your specifications.
References
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6-Fluoronicotinic Acid Supplier and Manufacturer
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