PRODUCT
6-Methyluracil CAS 626-48-2
CAS:626-48-2 | C5H6N2O2 |MW：126.11 | EINECS NO：210-949-4
Payment: L/C,T/T,D/P,Paypal,Money Gram,Western Union
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Transporta: Ocean, Land,Air, DHL，TNT
Port: Shanghai Port, Qingdao Port
Description
Physical properties At room temperature, 6-Methyluracil appears as a white or off-white crystalline powder. It is easy to store, transport, and weigh precisely. This makes it a good physical form for chemical raw materials and pharmaceutical intermediates. Solubility is one of the most important physical properties. Water solubility is low but significant. The introduction of methyl groups to uracil increases its hydrophobicity, which is why it has a lower solubility in the water than uracil without modification. It can still be dissolved into hot water or prepared at room temperature to a specific concentration for testing biological reactions. Solubility of 6-Methyluracil in organic solvents: Dimethyl sulfoxide is soluble with certain polar solvents. DMSO is a common solvent used to dissolve many insoluble compounds. It may also be slightly solubilized in dimethylformamide and alkaline aqueous solution. The processing method for experiments and production is determined by the solubility characteristics. Stability and melting point: 6-Methyluracil is an organic crystal with a high melting point. This shows good thermal stability, which makes it easy to store under normal conditions. The solid form of the material can be stable for a long period under dark and dry conditions. Chemical properties The main chemical properties of 6-Methyluracil can be attributed to the two functional groups that are present on the pyrimidine rings: an inert methyl and two amides. Due to its imines, pyrimidine can exhibit extremely weak acidity. The nitrogen atoms can accept protons weakly, and display extremely weak alkalinity. It is an amphoteric compound. However, its acidity and alkalinity levels are low, and the 6-Methyluracil molecule exists mainly in aqueous solution. Hydrogen bonding: The carbonyl oxygen in the 6-Methyluracil is a good hydrogen bond donor and acceptor, just like uracil. This property is important for simulating and interacting biomolecules. 6-Methyluracil is a molecular recognition network that can be involved in many biological activities. Aromaticity: The pyrimidine system is aromatic and a p-electrons conjugated system. The resonant structure of the ring system makes it relatively stable. However, the carbon atoms in the ring are less active for electrophilic replacement reactions. The 6-Methyluracil can be produced by using the reactivity in the uracil system. Reactivity of the methyl group. The methyl at position 6 may have some acidity due to its proximity with two electron-withdrawing nitrogen atoms. This allows it to participate in certain condensation reactions such as reacting with aldehydes and side chain derivatives. In most biologically-active scenarios, the methyl group at position 6 is regarded as an inert hydrophobic, playing a major role in steric hinderance and molecular polarity.
Product Images & Packaging
Product Parameters
| 6-Methyluracil Chemical Properties |
| Melting point | 318 °C (dec.)(lit.) |
| density | 1.226±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| pka | pK1:9.52 (25°C) |
| form | Fine Crystalline Powder |
| color | White to almost white |
| Water Solubility | 7 g/L (22 ºC) |
| Merck | 14,6133 |
| BRN | 115647 |
| InChI | InChI=1S/C5H6N2O2/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9) |
| InChIKey | SHVCSCWHWMSGTE-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(C)=CC(=O)N1 |
| CAS DataBase Reference | 626-48-2(CAS DataBase Reference) |
The application of 6-Methyluracil
Its value is mainly shown by its role as a core structure for bioactive molecules, and as an intermediate fine chemical.
1. Pharmaceutics: a key role in research and synthesis
This is where 6-methyluracil can be most useful. It is a key pharmaceutical intermediate that forms the basis for many important drugs.
Synthesis of anticancer drug: Some chemotherapy drugs contain modified pyrimidine base in their structure, like one of the metabolites from capecitabine. The 6-methyluracil is a useful starting material or intermediate in the synthesis for fluorouracil derivatives. Fluorouracil is a pyrimidine antimetabolite that inhibits the thymidine synthesis enzyme, interferes in DNA synthesis and suppresses cancerous cells. Modifying uracil using methylation or other techniques allows medicinal chemists to optimize the pharmacokinetics of the parent drug, for example, by improving the oral bioavailability and altering the tissue distribution.
Nucleoside analogs are used to develop drugs that target DNA viruses, such as the herpes virus. These analogues can be designed with non-natural bases, such as 6-methyluracil. They are then phosphorylated selectively by viral encoded enzymes, like thymidine Kinase, and integrated into viral DNA, resulting in antiviral effects.
Other drug development: It can be used as an analog of pyrimidine base to develop drugs to treat other diseases that are related to cell proliferation and genetic information transmission. Researchers can screen for inhibitory or activating activities against specific targets, such as receptors and enzymes. They do this by integrating the molecules into more complex molecular structures.
2. Plant Growth Regulation – Application in Agricultural Science
The 6-methyluracil has an important role in agriculture. It is being studied as a possible plant growth regulator.
Mechanism of Action: Its antimetabolic effects in animals may have a similar mechanism of action. It may disrupt the normal pyrimidine metabolic pathway in plants as an analog of uracil. Plants may mistake it for thymine or uracil, which then can be incorporated into the RNA, or disrupt the normal growth cycle and division of cells.
Use: The interference can have a growth inhibitory or regulatory effect at low concentrations. It is useful to promote tillering and control overgrowth. It may have herbicidal effects at higher concentrations. It is a metabolic antagonist, which inhibits metabolic processes in a competitive manner by simulating essential substances to life. This application is not as common as the mainstream herbicides but it has value for specific crops and research fields.
3. Applications of Biochemistry and Molecular Biology Research
In the area of basic science research, 6-methyluracil can be a helpful tool molecule.
Inhibitors are useful tools in enzymatic research. They can be used to study a variety of enzymes involved in pyrimidine metabolism. When studying enzymes like dihydropyrimidine (DPD), Thymidine Synthase and Uridine Phosphorrylase, 6-methyluracil is a good competitive inhibitor. Scientists can determine the mechanism of action and active center of enzymes by observing the effect of 6-methyluracil on the catalytic efficiency towards natural substrates such as thymine or uracil.
Cornerstone of nucleoside analogue synthesis: 6-methyluracil is a modified base that can be attached to either ribose (or deoxyribose) to create novel molecules. These molecules are useful for studying the properties of DNA/RNA or synthases or creating new diagnostic probes.
6-Methyluracil's Procurement Guide
Procurement Guidelines
1. Sample Policy
We can provide a 2-3g free trial package (shipping fee required)
2. Batch procurement
Packaging: 25kg/bag; 220kg/barrel; Special packaging according to your needs
MOQ：1kg
3. Customized services
Concentration customization (90% -99%)
Paeonol’s outsourcing services
FAQ
Yes, we have our own factory called ” ZhiShang Industry Group “
Yes, we have GMP certificate for some products, and we can provide DMF as well.
-Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Escrow and T/T in advance are highly recommended. We can accept Western Union, Money Gram and Paypal as well.
For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 day.
Related References
Manufacturer of 6-Methyluracil
Achievements
Advantage
Service
FAQ
Advice on Shipping
Achievements
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional 6-Methyluracil manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Advantage
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Service
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
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Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.
