Acacetin (CAS 480-44-4) | Natural Flavonoid with Multifunctional Bioactivities
Product Concept
Acacetin (CAS 480-44-4), a naturally occurring O-methylated flavone with the molecular formula C₁₆H₁₂O₅, is widely recognized for its exceptional pharmacological potential. This bioactive compound, primarily derived from Chrysanthemum morifolium and Apium graveolens, demonstrates remarkable antioxidant capacity with an ORAC value of 12,500 μmol TE/g. With a molecular weight of 284.26 g/mol and melting point of 258-260°C, this pale yellow crystalline powder exhibits optimal solubility in DMSO (25 mg/mL) and ethanol (8 mg/mL). Its unique molecular structure enables simultaneous interaction with multiple biological targets, making it a prime candidate for drug discovery and nutraceutical development.
Technical Specifications
- Molecular Formula: C₁₆H₁₂O₅
- Molecular Weight: 284.26 g/mol
- Purity: ≥98% (HPLC)
- Appearance: Pale yellow crystalline powder
- Melting Point: 258-260°C
- Solubility: DMSO (25 mg/mL), Ethanol (8 mg/mL)
- Storage: -20°C protected from light
Mechanistic Actions
- Anti-inflammatory: Inhibits NF-κB and COX-2 pathways (IC₅₀ = 5.2 μM)
- Anticancer: Induces apoptosis via Bcl-2/Bax regulation
- Antioxidant: Scavenges free radicals with TEAC value 2.3
- Antiviral: Blocks viral entry through ACE2 interaction
Multidisciplinary Applications
Pharmaceutical Development
- Lead compound for anticancer drugs
- Neuroprotective agent in Alzheimer’s research
- Anti-arthritis formulation development
- Cardioprotective supplement ingredient
Nutraceuticals
- Functional food additives
- Sports nutrition supplements
- Anti-aging formulations
Cosmeceuticals
- Anti-UV skincare products
- Collagen synthesis enhancers
- Topical anti-inflammatory creams
Extraction & Synthesis
- Supercritical CO₂ extraction from plant sources
- Microwave-assisted enzymatic hydrolysis
- Chemical synthesis from apigenin precursors
- Biotransformation using engineered yeast
Quality Assurance
- HPLC-DAD purity verification
- LC-MS/MS for structural confirmation
- Residual solvent analysis (GC-MS)
- Heavy metal testing (ICP-MS)
- Microbiological contamination checks
Safety Profile
- Acute Toxicity: LD₅₀ > 2000 mg/kg (oral, rat)
- Genotoxicity: Ames test negative
- Skin Irritation: Non-irritating (OECD 439)
- Ecotoxicity: Readily biodegradable