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Acetaminophen

Zhishang Bio Acetaminophen CAS 103-90-2

CAS:103-90-2 | C8H9NO2 |MW:151.16 | EINECS NO:203-157-5

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Acetaminophen
Acetaminophen
Acetaminophen

Describe

Acetaminophen, also known as acetaminophen, is a commonly used antipyretic and analgesic medication. Acetaminophen can inhibit the synthesis of prostaglandins and has antipyretic and analgesic effects.

Acetaminophen was first synthesized by Morse in 1878 and first used clinically by VonRinging in 1893. It became an over-the-counter drug in the United States in 1955, and production began in China in the late 1950s.

Acetaminophen appears as white crystalline or crystalline powder with a melting point of 168-172 ℃. It is odorless and has a slightly bitter taste. Acetaminophen is easily soluble in hot water or ethanol, soluble in acetone, and almost insoluble in cold water and petroleum ether.

Acetaminophen is stable below 45 ℃, but if exposed to humid air, it will hydrolyze into aminophenol, which will then undergo further oxidation, gradually turning pink, brown, and finally black in color. Therefore, Acetaminophen should be stored in a cool, dry, and sealed place.

Acetaminophen Chemical Properties
Melting point 168-172 °C(lit.)
Boiling point 273.17°C (rough estimate)
density 1,293 g/cm3
vapor pressure 0.008Pa at 25℃
refractive index 1.5810 (rough estimate)
Fp 11 °C
storage temp. Inert atmosphere,Room Temperature
solubility ethanol: soluble0.5M, clear, colorless
form Crystals or Crystalline Powder
pka9.86±0.13(Predicted)
color White
PH Range5.5 – 6.5 (H?O, 20 °C) (saturated solution)
PH5.5-6.5 (H2O, 20℃)(saturated solution)
Odorodorless
explosive limit15%(V)
Water Solubility 14 g/L (20 ºC)
Merck 14,47
BRN 2208089
BCS Class3,4
InChIKeyRZVAJINKPMORJF-UHFFFAOYSA-N

Application

Acetaminophen, as a chemical raw material, has various applications in the fields of medicine, chemical engineering, etc., mainly including the following aspects:

1. Pharmaceutical intermediates
Acetaminophen is a key intermediate in the synthesis of various drugs. For example, Acetaminophen can be used to prepare the active ingredients of phosphomycin tromethamine (an antibiotic) and certain compound analgesics. In addition, acetaminophen can be used as a precursor compound for the development of sustained-release or targeted delivery systems in pharmaceutical formulations.

2. Chemical synthesis
In the field of fine chemicals, Acetaminophen can be used as a raw material to participate in the synthesis of azo dyes, antioxidants, and polymer material modifiers. The benzene ring structure and active amino and hydroxyl groups of Acetaminophen make it suitable for organic synthesis reactions such as esterification, condensation, etc.

3. Laboratory research
In the field of scientific research, acetaminophen is commonly used in drug metabolism studies as a standard substance for liver toxicity models, used to evaluate the effects of drugs on the liver. In addition, acetaminophen is also used in analytical chemistry as a reference substance for high-performance liquid chromatography (HPLC) or mass spectrometry (MS).

4. Veterinary drugs and feed additives
In veterinary medicine, acetaminophen raw materials can be used to prepare antipyretic and analgesic drugs for animals, but the dosage needs to be strictly controlled because some animals (such as cats) have poor metabolic capacity for acetaminophen, which can easily cause poisoning.

Related References

Manufacturer of Nonyl Acetate

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