PRODUCT
Zhishang Bio Acrivastine CAS 87848-99-5
CAS:87848-99-5 | C22H24N2O2 |MW：348.44 | EINECS NO：*
Payment: L/C,T/T,D/P,Paypal,Money Gram,Western Union
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Transporta: Ocean, Land,Air, DHL，TNT
Port: Shanghai Port, Qingdao Port
Product Images & Packaging
Describe
Acrivastine, a second generation antihistamine drug, has a molecular formula of C 2 2H 2 4N 2 O 2, and a weight molecular of 348.45g/mol.
Acrivastine is a member of the class of acrylic acids derivatives. It has a stronger H1 receptor selectivity, lower central nervous inhibition and does not cause drowsiness.
Acrivastine comes as a white powder or off-white powder. It is slightly soluble (but not easily) in water, and is easily soluble (but not very readily) in organic solvents like methanol and alcohol. The synthesis of acrivastine usually begins with p-methylbenzaldehyde, followed by pyrrolidine and multiple reactions, such as condensation and cyclization.
Acrivastine must meet international standards for pharmacopoeia, control all relevant substances, residual solvents and microbial levels to ensure safety and efficacy of the formulation.
Acrivastine, in clinical practice is used primarily to relieve allergic symptoms like allergic rhinitis or urticaria. Acrivastine’s fast onset and short-term duration of action make it ideal for patients with symptoms that need relief quickly and without sedative effects.
Acrivastine is relatively safe for liver function due to its low metabolism dependence. However, patients with severe kidney insufficiency may need to adjust their dosage.
| Acrivastine Basic information |
| Product Name: | Acrivastine |
| Synonyms: | (e)-3-[6-[(e)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid;ACRIVASTINE;Acrivastin; |
| CAS: | 87848-99-5 |
| MF: | C22H24N2O2 |
| MW: | 348.44 |
| EINECS: | |
| Product Categories: | API |
| Mol File: | 87848-99-5.mol |
| Acrivastine Chemical Properties |
| Melting point | 222° (dec) |
| Boiling point | 555.1±50.0 °C(Predicted) |
| density | 1.170±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >2mg/mL (warmed) |
| form | powder |
| pka | 1.99±0.10(Predicted) |
| color | white to beige |
| Stability: | Light Sensitive |
Application
Acrivastine belongs to the second-generation of antihistamines and is a selective antagonist H1 receptor.
Acrivastine is a chemical with a high affinity to H1 receptors. Its high polarity makes it difficult to cross the blood-brain barriers. Acrivastine is less likely to cause side effects in the central nervous system compared to first-generation antihistamines.
Acrivastine works primarily by blocking histamine binding to H1 receptors. This inhibits allergic reactions caused by histamine, such as capillary dilation or increased vascular permeability.
Acrivastine, from a pharmacokinetic point of view, is rapidly absorbed following oral administration. It takes effect within 30 minutes, and reaches peak blood concentration in 1-1.5 hours.
Acrivastine’s plasma protein binding is approximately 50%, and its elimination half-life is about 1.5-2 hours. The liver is only responsible for a small portion of the metabolized drug. It is excreted primarily in its original form. It is a metabolic characteristic that requires a dose adjustment for patients with renal failure, but it has comparatively little impact on the liver’s function.
Acrivastine has a duration of 8-12 hours. Therefore, the usual clinical dosage is once every 8 hour.
Acrivastine has a wide range of clinical applications. It is used to treat allergic diseases such as allergic rhinitis and urticaria.
Acrivastine is effective in relieving the symptoms of seasonal allergy rhinitis. This includes nasal itching, runny nose, and sneezing. Acrivastine is difficult to cross the blood-brain barriers, so it does not cause central inhibitory symptoms like drowsiness, even at recommended doses. This makes it ideal for patients who must maintain alertness.
Acrivastine is less likely to interact with other drugs, so it does not require any special adjustments in dosage when combined with erythromycin or ketoconazole.
Acrivastine is relatively safe and has a low incidence of side effects. Mild dry mouth, headaches, and gastrointestinal discomfort are common adverse reactions, but severe reactions are rare. Contraindications include those who are allergic to this drug or have severe renal failure.
Acrivastine is a relatively mild central nervous system drug, but individual reactions can still occur. It is important to monitor the patient during the initial stages of treatment.
Acrivastine is a safe and fast-acting antihistamine that has a significant role in treating allergic symptoms.
Related References
Manufacturer of Acrivastine
Achievements
Advantage
Service
FAQ
Advice on Shipping
Achievements
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional Acrivastine manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Advantage
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Service
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.
