PRODUCT
Zhishang Bio Bicalutamide CAS 90357-06-5
CAS:90357-06-5 | C18H14F4N2O4S |MW：430.37 | EINECS NO：200-001-8
Payment: L/C,T/T,D/P,Paypal,Money Gram,Western Union
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Transporta: Ocean, Land,Air, DHL，TNT
Port: Shanghai Port, Qingdao Port
Product Images & Packaging
Describe
Bicalutamide is a nonsteroidal antiandrogen medication mainly used for the therapy of prostate cancer. The physicochemical residential or commercial properties of its basic materials directly influence the formula procedure, stability, and bioavailability of the medication.
1. Physical residential or commercial properties
Appearance and Kind: Bicalutamide API is usually a white or off white crystalline powder without odor or a small characteristic odor.
Solubility:
Water solubility: Bicalutamide is extremely slightly soluble in water and belongs to improperly soluble medications.
Organic solvent solubility: Bicalutamide is conveniently soluble in polar organic solvents such as dimethyl sulfoxide, methanol, ethanol, acetone, and slightly soluble in chloroform and ether.
Melting point: Bicalutamide has a melting point of roughly 191-195 ° C, indicating its high thermal security.
Crystal type: Bicalutamide might exhibit polymorphic phenomena, and different crystal types might impact solubility and bioavailability, which need to be regulated throughout the formula process.
2. Chemical homes
Chemical framework: The molecular formula of Bicalutamide is C18H14F4N2O4S, having a sulfonylurea group and a fluorine substituted benzene ring. The framework is secure but prone to strong acids, bases, or oxidants.
Acidity and alkalinity: Bicalutamide is a weakly acidic compound that is much more soluble under alkaline problems.
Stability:
Light stability: Bicalutamide is sensitive to light and may weaken when exposed to ultraviolet light for a long period of time. It needs to be saved away from light.
Thermal security: Stable in the strong state, however high temperatures might create decomposition.
Hydrolysis security: Bicalutamide might go through hydrolysis under solid acid or alkali conditions, and severe pH atmospheres should be stayed clear of.
3. Spectral characteristics
UV absorption: Bicalutamide has particular absorption comes to a head at roughly 270 nm and 220 nm, which can be used for web content determination and quality control.
Infrared spectroscopy: displays particular absorption bands of sulfonamide, carbonyl, and aromatic rings.
4. Moisture absorption
Bicalutamide basic material has reduced hygroscopicity, however may slightly soak up wetness in high humidity settings and requires to be kept under completely dry conditions.
| Product Name: | Bicalutamide |
| Synonyms: | (+-)–2-hydroxy-2-methyl; |
| CAS: | 90357-06-5 |
| MF: | C18H14F4N2O4S |
| MW: | 430.37 |
| EINECS: | 200-001-8 |
| Product Categories: | MODRASTANE; |
| Mol File: | 90357-06-5.mol |
| Bicalutamide Chemical Properties |
| Melting point | 191-193°C |
| Boiling point | 650.3±55.0 °C(Predicted) |
| density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >5mg/mL |
| pka | 11.49±0.29(Predicted) |
| form | powder |
| color | White to Off-White |
| λmax | 270nm(CH3CN)(lit.) |
| Merck | 14,1200 |
Application
Bicalutamide is a nonsteroidal antiandrogen drug primarily used for the treatment of prostate cancer
1. Active ingredients of drugs
Bicalutamide competitively binds to androgen receptors, blocking the action of androgens in the body and inhibiting the growth of prostate cancer cells.
Bicalutamide is often used in combination with gonadotropin-releasing hormone analogs for the treatment of advanced prostate cancer.
2. Clinical application
Prostate cancer treatment:
Bicalutamide, as a first-line treatment drug, delays disease progression.
Bicalutamide is used as an adjuvant or neoadjuvant therapy to reduce tumor volume.
Bicalutamide is used in combination with surgery or radiation therapy to improve treatment efficacy.
3. Pharmacological mechanism
Bicalutamide binds to androgen receptors, preventing androgen activation of receptors and thereby inhibiting cancer cell proliferation.
Bicalutamide is well absorbed orally with a long half-life, making it suitable for once daily administration.
4. Chemical synthesis
The chemical raw materials of Bicalutamide are used to synthesize its active ingredients. The synthetic route involves multiple reactions, ultimately forming compounds with anti androgen activity.
Related References
Manufacturer of Bicalutamide
Achievements
Advantage
Service
FAQ
Advice on Shipping
Achievements
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional Bicalutamide manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Advantage
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Service
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.
