Capecitabine CAS 154361-50-9 Supplier & Factory | High Purity API | Zhishang Bio
Capecitabine CAS 154361-50-9
- Surfactant Appearance: POWDER
- Proportion: Minimum 99.0%
- Inventory: In stock
- Sample: In stock
- Zhishang Chemical: Supplier and manufacturer of Capecitabine CAS 154361-50-9
Basic Info of Capecitabine
| Dibutyl phthalate Chemical Properties |
| Melting point | -35 °C (lit.) |
| Boiling point | 340 °C (lit.) |
| density | 1.043 g/mL at 25 °C (lit.) |
| vapor density | 9.6 (vs air) |
| vapor pressure | 1 mm Hg ( 147 °C) |
| refractive index | n20/D 1.492(lit.) |
| Fp | 340 °F |
| storage temp. | 2-8°C |
| solubility | Very soluble in alcohol, ether, acetone, benzene |
| form | Liquid |
What is Capecitabine?
Capecitabine (CAS 154361-50-9), identified by chemical formula C₁₅H₂₂FN₃O₆ and molecular weight 359.35 g/mol, is a fluoropyrimidine carbamate derivative supplied as a white to off-white crystalline powder. Structurally designated as pentyl [1 – (3, 4-dihydroxy-5-methyloloxolan-2-yl) – 5-fluoro-2-oxo-1, 2-dihydropyrimidin-4-yl]carbamate, this organic intermediate exhibits high solubility in methanol, ethanol, and organic solvents, with controlled water solubility under ambient conditions (26.0 mg/mL at 20°C).
As an essential active pharmaceutical intermediate and fine chemical building block, Capecitabine functions as an oral prodrug of 5-fluorouracil (5-FU). Its unique three-step enzymatic conversion cascade—culminating in localized conversion via thymidine phosphorylase—makes it a benchmark chemical raw material for complex formulation synthesis and solid dosage form manufacturing. The compound requires precise moisture regulation and strict thermal storage conditions (2°C to 8°C or dry room temperature below 25°C) to prevent hydrolytic degradation of the carbamate linkage.
Product Packaging
If you want to buy Capecitabine, pls contact us to get a free quote.
Superior Capecitabine Series | Reliable Quality & Sufficient Supply
At Shandong Zhishang Biological Co., Ltd., we operate modernized organic synthesis reaction workshops equipped with automated glass-lined reactors, multi-stage crystallization systems, and specialized vacuum drying units. Our dedicated synthesis route optimizes the coupling and acylation steps to eliminate persistent trace impurities (such as unreacted 5-deoxy-1, 2, 3-tri-O-acetyl-D-ribofuranose derivatives), ensuring superior crystalline stability and batch-to-batch reproducibility.
To fulfill the rigorous supply chain demands of global pharmaceutical manufacturers and R&D institutions, Zhishang Bio provides reliable technical and commercial backing:
- Production Capacity:Dedicated annual capacity of 5 Metric Tons (MT) for high-grade Capecitabine raw material.
- Warehouse Stock:Over 150 kg of ready stock maintained in our temperature-controlled Jinan warehouse for immediate dispatch.
- HPLC Purity Control:Standard production batches achieve ≥ 0% assay purity (HPLC), with single maximal impurity controlled below 0.10% and total related substances under 0.50%.
- Trace Solvent & Heavy Metal Safeguards:Residual solvents (including methanol, toluene, and pyridine) are tightly controlled well below ICH Q3C limits, with heavy metal content maintained at < 10 ppm.
- Global Logistics & Packaging:Available in 100g, 1kg aluminum foil bags for laboratory testing, and 10kg / 25kg double-PE lined anti-static fiber drums for commercial manufacturing.
FAQ
Capecitabine dissolves readily in organic solvents like ethanol, methanol, and anhydrous DMF, but shows moderate water solubility. For wet granulation or liquid synthesis processes, pre-dissolving the raw material in an ethanol/polyol co-solvent system at controlled temperatures (35°C – 45°C) ensures uniform distribution. Avoid sustained heating above 60°C in acidic or strongly alkaline media to prevent premature hydrolysis.
We enforce strict raw material auditing for intermediate reagents and utilize nitrogen-blanketed crystallization. This prevents air-induced oxidation and thermal degradation during isolation, consistently yielding a pure white crystalline powder with single impurity levels held well under 0.10%.
Every shipment from Zhishang Bio is accompanied by a complete technical dossier, including:
- Batch-specific Certificate of Analysis (COA)
- GHS-compliant Safety Data Sheet (SDS/MSDS)
- Technical Data Sheet (TDS) & HPLC purity spectra
- Stability testing data and residual solvent certificates upon request.
We offer scalable order quantities to accommodate both formulation development and full production runs:
- Evaluation Samples:10g – 100g analytical samples dispatched via air courier within 24 hours.
- Commercial MOQ:1 kg.
- Lead Time:Stock orders ship within 3-5 business days. Tiered volume pricing applies to orders exceeding 10 kg, 50 kg, and 100 kg.
References
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
Capecitabine Supplier and Manufacturer
As a Capecitabine supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best Capecitabine raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for Capecitabine and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Our laboratory
Certificates and patents
Hot Products
