PRODUCT
5-Aminolevulinic acid methyl ester hydrochloride
CAS:79416-27-6 | C6H12ClNO3 |MW：181.62 | EINECS NO：279-151-1
Payment: L/C,T/T,D/P,Paypal,Money Gram,Western Union
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Transporta: Ocean, Land,Air, DHL，TNT
Port: Shanghai Port, Qingdao Port
Description
5-Aminolevulinic acid methyl ester hydrochloride, also known by its acronym ALA-M, is an invaluable organic compound with applications in medicine, pesticides, cosmetics and photodynamic therapy.
Due to its remarkable combination of biological activity and chemical properties, 5-Aminolevulinic acid methyl ester hydrochloride has quickly become one of the focal points for research in both chemical applications as well as industrial research applications.
Chemical Properties of 5-Aminolevulinic Acid Methyl Ester Hydrochloride
5-Aminolevulinic Acid Methyl Ester Hydrochloride has a molecular structure containing one carboxylate group, one ketone group, an amino group and one hydrochloride group; these four functionalities conferring it various distinct chemical properties.
Due to its carbonyl ester and ketone groups, 5-Aminolevulinic acid methyl ester hydrochloride exhibits electrophilicity that allows it to undergo addition reactions with nucleophiles to produce new compounds.
On top of this, the amino group makes this compound alkaline and allows it to undergo acid-base reactions with acids to generate salts. 5-Aminolevulinic acid methyl ester hydrochloride also boasts excellent photostability and remains stable under light conditions for use in fields like photodynamic therapy.
Product Images & Packaging
Product Parameters
| 5-Aminolevulinic acid methyl ester hydrochloride Chemical Properties |
| Melting point | 119-121° |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | very faint turbidity |
| Sensitive | Light Sensitive/Hygroscopic |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C6H11NO3.ClH/c1-10-6(9)3-2-5(8)4-7;/h2-4,7H2,1H3;1H |
| InChIKey | UJYSYPVQHFNBML-UHFFFAOYSA-N |
The application of 5-Aminolevulinic acid methyl ester hydrochloride
Photodynamic Therapy and Diagnosis
These are two primary applications for 5-Aminolevulinic acid methyl ester hydrochloride in medical fields: Photodynamic Therapy and Diagnosis. Their mechanism of action lies within the porphyrin biosynthesis pathway:
Basic Principle:
5-Aminolevulinic acid methyl ester hydrochloride when applied locally to diseased tissue is quickly absorbed by cells and processed through its endogenous heme biosynthesis pathway, producing large quantities of photosensitive substance called Protoporphyrin IX.
Normal cell metabolism and clearance of PpIX occur more quickly, while pathological changes may produce and accumulate high amounts of it due to metabolic anomalies.
When these pretreated areas are exposed to light of specific wavelengths, PpIX found in diseased cells is activated through photochemical reactions that create singlet oxygen and free radicals – producing singlet oxygen and free radicals which selectively destroy target cells without harming nearby normal tissues. Here are a few clinical applications:
Photodynamic Diagnosis-Fluorescent Cystoscopy for Bladder Cancer: mes Fluorescent cystoscopy can provide invaluable assistance when diagnosing nonmuscle-invasive bladder cancer; traditional white light cystoscopy tends to miss flat, small lesions that may indicate early cancer formation and precancerous cells that form early signs.
Method: Inject 5-Aminolevulinic acid methyl ester hydrochloride solution into your bladder for a specified time, and use a blue light cystoscope for further examination.
Effect: Cancerous tissues that accumulate a high concentration of PpIX emit strong red fluorescence that stands out against its background of blue, providing better detection rate of bladder cancer than traditional white light microscopy and helping doctors conduct biopsies and resection more precisely while decreasing risk of recurrence. Photodynamic therapy:
Dermatology Application – Treating Actinic Keratosis: Usage: Actinic keratosis is a precancerous skin lesion typically caused by sun exposure over an extended period, with potential to progress into squamous cell carcinoma. 5-Aminolevulinic acid methyl ester hydrochloride has been approved as treatment for mild to moderate actinic keratosis of the face and neck.
Method: After applying the cream formulation of the drug to the affected area, incubate for several hours, and then use red light irradiation, it has the advantage of high selectivity, superior cosmetic effect and ability to treat large and subclinical lesions.
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Dermatology Application – Basal Cell Cancer:
For superficial basal cell cancers, ALA-PDT offers an effective noninvasive alternative when surgery isn’t appropriate or the patient wishes not to undergo surgery.
Exploration in other therapeutic fields:
Research shows that its application continues to expand into additional fields of medicine, such as treating Bowen’s disease, acne, viral warts and certain precancerous lesions found both gynecologically and digestive tract.
2. Compare to Other Derivatives 5-Aminolevulinic acid methyl ester hydrochloride is an esterified derivative of 5-ALA that offers distinct clinical benefits: This modification creates a significantly stronger structure and thus offers several distinct clinical advantages:
Strong Lipid Solubility: Thanks to its ester group, 5-ALA is much more lipid soluble than water-soluble. This means it can easily penetrate cell membranes and tissue barriers such as keratinized skin to be efficiently taken up by cells.
Higher conversion efficiency: Due to its ease of entry into cells, PZI can more readily be converted to protoporphyrin IX within them.
Shorter Incubation Time: In order to reach effective concentration of PpIX faster, incubation times have become shorter. For instance, photodynamic therapy for skin uses 5-ALA in its formulation which requires up to 6-8 hours incubation while 5-Aminolevulinic Acid Methyl Ester Hydrochloride may only need 3 hours and causes less patient inconvenience.
Deeper Tissue Penetration: While 5-ALA is usually reserved for superficial lesions, its properties enable it to act slightly deeper.
Therefore, although 5-ALA also serves a similar function, 5-Aminolevulinic acid methyl ester hydrochloride is generally considered more efficient and optimized; especially in dermatological applications where it has become one of the gold standards.
5-Aminolevulinic acid methyl ester hydrochloride's Procurement Guide
Procurement Guidelines
1. Sample Policy
We can provide a 2-3g free trial package (shipping fee required)
2. Batch procurement
Packaging: 25kg/bag; 220kg/barrel; Special packaging according to your needs
MOQ：1kg
3. Customized services
Concentration customization (90% -99%)
Paeonol’s outsourcing services
FAQ
Yes, we have our own factory called ” ZhiShang Industry Group “
Yes, we have GMP certificate for some products, and we can provide DMF as well.
-Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Escrow and T/T in advance are highly recommended. We can accept Western Union, Money Gram and Paypal as well.
For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 day.
Related References
Manufacturer of 5-Aminolevulinic acid methyl ester hydrochloride
Achievements
Advantage
Service
FAQ
Advice on Shipping
Achievements
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional 5-Aminolevulinic acid methyl ester hydrochloride manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Advantage
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Service
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.
