PRODUCT
Rabeprazole Sodium CAS 117976-90-6
CAS:117976-90-6 | C18H21N3O3S.Na |MW：382.43 | EINECS NO：629-730-3
Payment: L/C,T/T,D/P,Paypal,Money Gram,Western Union
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Transporta: Ocean, Land,Air, DHL，TNT
Port: Shanghai Port, Qingdao Port
Description
Rabeprazole Sodium and Omeprazole are both proton pump inhibitors. The so-called proton pump, also known as H+/K+- ATPase, is the final stage of gastric acid secretion. Proton pump inhibitors can efficiently and rapidly inhibit proton pumps and reduce gastric acid secretion. They are currently the most advanced class of drugs for treating gastrointestinal diseases such as gastric and duodenal ulcers, reflux esophagitis, and Helicobacter pylori infection. Proton pump inhibitors are more specific, have a longer duration, and produce a stronger acid suppression effect than other types. The chemical name of Rabeprazole Sodium is 2- [[4- (3-methoxypropoxy) -3-methylpyridin-2-yl] methylsulfonyl] -1H benzimidazole sodium. This lengthy name accurately describes its molecular composition. 1. Core skeleton: Benzimidazole and pyridine ring: Rabeprazole Sodium, like other proton pump inhibitors such as omeprazole and lansoprazole, shares a core structure – the benzimidazole ring is connected to a substituted pyridine ring. This basic skeleton is the cornerstone for exerting pharmacological effects. 2. Key linkage: Sulfonyl group: The linkage between two rings is a key sulfonyl group, which makes Rabeprazole Sodium belong to the “sulfonyl benzimidazole” class of compounds. This sulfonyl group is the key site for its conversion into its active form in the body. 3. Unique substituents: Source of competitive advantage: Compared with the first generation PPI omeprazole, Rabeprazole Sodium introduces a unique substituent of “3-methoxypropoxy” at position 4 of the pyridine ring. This structural modification is the chemical basis for optimizing its pharmacokinetics and pharmacodynamics. Rabeprazole Sodium is not a prodrug, reducing its dependence on the liver cytochrome P450 enzyme system, resulting in faster onset of action and more predictable individual responses.
Product Images & Packaging
Product Parameters
| Rabeprazole Sodium Chemical Properties |
| Melting point | 140-141°C dec. |
| storage temp. | -20°C |
| solubility | H2O: soluble10mg/mL (clear solution) |
| form | powder |
| color | white to beige |
| Water Solubility | H2O: 10mg/mL (clear solution) |
| Merck | 14,8089 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1 |
The application of Paeonol
Rabeprazole Sodium is approved for the treatment of a range of acid related diseases based on its strong acid suppressing ability and excellent pharmacokinetic properties, and is often one of the preferred drugs.
1. Gastroesophageal reflux disease: This is the main indication for Rabeprazole Sodium. GERD is a disease characterized by discomfort and complications caused by the reflux of gastric contents into the esophagus. Rabeprazole Sodium can strongly inhibit gastric acid secretion, quickly alleviate typical symptoms such as heartburn and acid reflux, and promote the healing of damaged esophageal mucosa. For erosive esophagitis, the healing rate is very high.
2. Peptic ulcer disease:
Duodenal ulcer and gastric ulcer: Rabeprazole Sodium can effectively inhibit gastric acid and create a good healing environment for ulcers.
3. Eradicating Helicobacter pylori: Helicobacter pylori infection is the main cause of peptic ulcers. Rabeprazole Sodium is a core component of “triple therapy” or “quadruple therapy”. The function is not only to inhibit gastric acid, but more importantly, to increase the pH value in the stomach, creating a more suitable active environment for the synergistic use of antibiotics, thereby significantly improving the eradication rate of Helicobacter pylori.
4. Zhuo Ai Syndrome: This rare condition is caused by gastrinoma and leads to an excessive gastric acid secretion. Rabeprazole Sodium is a powerful medication that can control stomach acid, and relieve severe and persistent peptic ulcers as well as diarrhea.
5. Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause damage to the mucosa of the stomach in patients who need long-term NSAIDs. Rabeprazole Sodium is a combination that can prevent and treat gastric damage and ulcers caused by NSAIDs.
6. Rabeprazole Sodium is an effective adjuvant for upper gastrointestinal hemorrhaging, particularly in cases of severe upper gastrointestinal blood loss, such as those caused by peptic ulcers. It can help to stabilize blood clots, and reduce the chance of rebleeding.
Adverse reactions and precautions: safety considerations
Although Rabeprazole Sodium is very safe and well tolerated, like all drugs, it is not without potential risks.
Common adverse reactions: usually mild and brief, including headache, dizziness, diarrhea, constipation, abdominal pain, nausea, bloating, etc. Most patients can tolerate it without stopping the medication.
Long-term risks: Nutritional malabsorption. Gastric acid is necessary for digestion and absorption. Long-term strong acid suppression can affect absorption of calcium, magnesium, and vitamin B12. Anemia and neurological disorders can be caused by a lack of vitamin B12; calcium absorption disorders increase the risk for osteoporosis, fractures and anemia in elderly people. Increased risk of infection. Gastric acid is a first line of defense in the fight against pathogens. Long-term acid suppression can increase the risk for intestinal infections and pneumonia acquired in the community. Changes in the gastric environment can also lead to an excessive growth of bacteria. Renal effects are rare, but caution is advised. Rabeprazole Sodium and gastric fundus polyps. Rabeprazole Sodium is associated with an increased chance of developing benign gastric fundus polyps. These polyps are monitored through gastroscopy.
Rabeprazole Sodium's Procurement Guide
Procurement Guidelines
1. Sample Policy
We can provide a 2-3g free trial package (shipping fee required)
2. Batch procurement
Packaging: 25kg/bag; 220kg/barrel; Special packaging according to your needs
MOQ：1kg
3. Customized services
Concentration customization (90% -99%)
Paeonol’s outsourcing services
FAQ
Yes, we have our own factory called ” ZhiShang Industry Group “
Yes, we have GMP certificate for some products, and we can provide DMF as well.
-Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Escrow and T/T in advance are highly recommended. We can accept Western Union, Money Gram and Paypal as well.
For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 day.
Related References
Manufacturer of Rabeprazole Sodium
Achievements
Advantage
Service
FAQ
Advice on Shipping
Achievements
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional Rabeprazole Sodium manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Advantage
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Service
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.
