What specific warehouse handling and temperature protocols prevent Isophosphamide white crystalline powder from melting?

This organophosphorus compound features a very low melting point of 48‑51 °C (118.4‑123.8 °F). Warehouse heat surges or mechanical friction during handling can liquefy the crystals and fuse them into solid agglomerates. The material also decomposes readily under light exposure. To secure its full 24‑month shelf‑life, store in hermetically‑sealed containers under dry nitrogen purge within a secured, dark cold‑storage area strictly kept at 2‑8 °C (35.6‑46.4 °F).

Bulk Isophosphamide CAS 3778-73-2 | Secure Sourcing & Ready Stock | Zhishang Bio

Q: What hazardous safety labels apply to Isophosphamide manifests, and what PPE do handlers require?

As a potent DNA‑alkylating intermediate, Isophosphamide falls under strict international dangerous‑goods shipping rules. It is categorized as acutely toxic, mutagenic, and hazardous to reproduction, with an animal‑study oral LD₅₀ around 143 mg/kg. Operators must wear suitable PPE: heavy‑duty nitrile gloves, chemical splash goggles, and positive‑pressure respirators. All powder manipulation must take place inside a certified negative‑pressure fume hood.

Q: How do you manage cross‑border shipping logistics and compliance dossiers for international Isophosphamide buyers?

High‑purity batches are packed in light‑blocking amber glass vials or heavy‑duty fluorinated plastic vessels with dedicated desiccants, and transported via temperature‑controlled cold‑chain transport. Our export team pre‑completes all dangerous‑goods manifests, region‑adapted GHS‑aligned SDS documents, and customs filing forms. Comprehensive pre‑documentation supports smooth port clearance and safe, punctual delivery to your site.

Bulk Isophosphamide CAS 3778-73-2

Surfactant Appearance: POWDER
Proportion: Minimum 99.0%
Inventory: In stock
Sample: In stock
Zhishang Chemical: Supplier and manufacturer of Isophosphamide

Basic Info of Isophosphamide

Ifosfamide Chemical Properties

Melting point	48°C
Boiling point	336.1±52.0 °C(Predicted)
density	1.33±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	DMF:50.0(Max Conc. mg/mL);191.51(Max Conc. mM) DMSO:44.0(Max Conc. mg/mL);168.53(Max Conc. mM) Ethanol:51.0(Max Conc. mg/mL);195.34(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);38.3(Max Conc. mM) Water:52.0(Max Conc. mg/mL);199.17(Max Conc. mM)
pka	1.44±0.20(Predicted)
form	Solid
color	White to off-white
Henry’s Law Constant	7.0×10⁵ mol/(m³Pa) at 25℃, HSDB (2015)

What is Isophosphamide?

Technical Overview: Isophosphamide (CAS 3778-73-2)

Isophosphamide (CAS 3778-73-2), chemically identified within global pharmacopoeia registries as an advanced oxazaphosphorine matrix carrying the molecular formula C₇H₁₅Cl₂N₂O₂P and a mass of 261.09, operates as an indispensable synthetic precursor and analytical reference standard within the oncology research sector. Synthesis engineers track this highly refined molecule primarily for its precise nitrogen mustard alignment, utilizing the structure to drive core reaction paths for advanced drug discovery and structure-activity relationship (SAR) exploration. Physically, this highly toxic substance presents as a distinct, white crystalline powder that features a sharp melting threshold between 48°C and 51°C. For precise processing layouts, the compound dissolves smoothly into liquid vehicles like water, methanol, and methylene chloride within your laboratory reaction flasks, requiring strict temperature control and zero exposure to moisture during incorporation.

The Specialized Low-Moisture Isolation Pathway

[Phosphorus Oxychloride Feed] + [Choroethylamine Chains] ➔ [Regiospecific Condensation Loop] ➔ [Vacuum Evaporative Crystallization] ➔ [Pure Isophosphamide ≥99.0%]

The bio-refining pathway mapped above illustrates our closed-loop synthesis sequence. By avoiding old, high-humidity isolation paths that trigger rapid ring-opening degradation, this specialized dry crystallization loop enforces the following rigid parameters across every single batch:

Analytical Parameter	Checked Value Profile	Operational Benefit
Active Isophosphamide Assay	≥ 99.00% (validated by HPLC)	Prevents enantiomeric anomalies
Total Moisture Weight	≤ 0.50% (Karl Fischer titration)	Eliminates premature ring hydrolysis
Heavy Metals Ceiling	≤ 10.00 ppm	Complies with strict regulatory monographs

Key Applications in Pharmaceutical R&D

1. API Synthesis & Medicinal Chemistry Blocks

Formulation teams utilize this ultra-pure alkylating building block as a baseline component to synthesize complex active ingredients. Its precise crystalline arrangement maps perfectly into organic condensation loops, linking cleanly with target amine fractions without triggering premature degradation of the core oxazaphosphorine ring system.

2. Analytical Reference Standards & QC Profiling

Quality assurance laboratories deploy our certified batches as benchmark reference materials for high-performance liquid chromatography (HPLC) validation and gas chromatography (GC) method development. Having this highly refined fraction ready upfront allows your regulatory compliance teams to build airtight impurity tracking data for ANDA documentation filings.

Product Packaging

If you want to buy Isophosphamide, pls contact us to get a free quote.

Superior Isophosphamide Series | Reliable Quality & Sufficient Supply

1. Constant Kilo-Scale Buffers & Secured Cold-Chain Storage
We shield your validation timelines from sudden raw material shortages by maintaining a constant, multi-tier inventory buffer of standard amber vials at our specialized temperature-controlled depots. Our synthesis assets operate continuous purification lines that support everything from micro gram-scale lots for laboratory screening to multi-kilogram freight campaigns for pilot scale-ups. This flexible asset grid ensures you completely bypass market procurement bottlenecks and raw material shocks. Whether your current analytical run requires a 10g testing vial or a full commercial lot drop, your cargo clears our transit dock within 48 hours under strict monitoring.
2. Advanced Low-Moisture Vacuum Crystallization Technology
Our technical division engineered a multi-stage low-temperature vacuum crystallization process that drops total residual moisture down to a strict maximum of 0.50%. This precise process control blocks unexpected ring-opening hydrolysis inside your melting vats, heavily lowering your downstream purification overheads and keeping melting points tightly bound between 48°C and 51°C. We monitor every fractionating lot via automated high-performance liquid chromatography (HPLC) to guarantee an exact active purity profile of ≥99.00% across multi-year contracts. Your quality assurance team receives an official, factory-direct Certificate of Analysis (COA) before the freight ever arrives at your plant door.

FAQ

Why does moisture control matter so much during the storage and synthesis of Isophosphamide?

It comes down to protecting the active oxazaphosphorine ring from rapid ring-opening degradation. This chemical matrix is highly hygroscopic; exposure to ambient humidity or trace water fractions triggers a rapid hydrolytic cleavage of the phosphorus-nitrogen bond. This hydrolysis forms unreactive acidic byproducts that alter your reaction kinetics and ruin your synthesis yields. Our 99% pure Isophosphamide undergoes advanced vacuum oven drying to keep moisture under 0.50%, ensuring complete structural stability during upstream blending.

What specific warehouse handling and temperature protocols prevent this white crystalline powder from melting?

This organophosphorus compound possesses an exceptionally low melting threshold of 48–51°C (118.4–123.8°F), meaning standard warehouse heat spikes or friction during mechanical handling will cause the crystalline lattice to liquefy and fuse into a solid mass. Furthermore, the molecule is highly sensitive to light-induced decomposition. To protect the complete 24-month shelf life, warehouse managers must store the material inside hermetically sealed containers under a dry nitrogen blanket held inside a secure, dark cold-storage facility maintained strictly at 2–8°C (35.6–46.4°F).

What hazardous safety labels apply to Isophosphamide manifests, and what PPE do handlers require?

Because the compound is a potent DNA-alkylating intermediate, it carries serious international hazardous shipping regulations. It is officially classified as a severe toxic substance, a proven mutagen, and a reproductive hazard, requiring an oral LD₅₀ monitoring threshold of approximately 143 mg/kg in animal models. Material handlers must always utilize appropriate personal protective equipment (PPE)—including heavy-duty nitrile gloves, chemical splash goggles, and positive-pressure respirators—and exclusively discharge the raw powder inside a certified negative-pressure fume hood.

How do you manage cross-border shipping logistics and compliance dossiers for international buyers?

We streamline cross-border shipping by packing our high-purity lots inside standard light-shielded amber glass vials or heavy-duty fluorinated plastic containers, packed with specialized desiccants and shipped under strict temperature-controlled cold-chain logistics. Our export desk manages all global hazardous manifests, localized GHS-compliant MSDS/SDS sheets, and customs clearance paperwork upfront. This rigorous preparation guarantees a hassle-free port crossing and a safe, on-time delivery directly to your facility door.

References

Pub-Isophosphamide

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Isophosphamide Supplier and Manufacturer

As a Isophosphamide supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best Isophosphamide raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for Isophosphamide and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.