Polyethylene Glycol CAS 25322-68-3 | High Purity price & Supplier
Polyethylene Glycol CAS 25322-68-3
- Surfactant Appearance: liquid
- Proportion: Minimum 99.0%
- Inventory: In stock
- Sample: In stock
- Zhishang Chemical: Supplier and manufacturer of Polyethylene Glycol
What is Polyethylene Glycol?
If you are sourcing organic raw materials and process excipients, you may often handle diverse molecular weights of Polyethylene Glycol. This polyether compound incorporates various physical states depending entirely on its chain length, meaning a single product category includes liquid vehicles, soft waxes, and dense solid flakes. Choosing the wrong grade can trigger formulation failures, alter dissolution rates, or compromise structural integrity in your end products.
Understanding these physical and chemical boundaries allows procurement teams to clear quality control checks, match exact application needs, and avoid unexpected production delays.
The fundamental distinction across the Polyethylene Glycol (PEG, CAS 25322-68-3) family centers on average molecular weight and polymer chain distribution. Low-range weights like PEG 200 through 600 present as clear, viscous liquids that act as powerful hydrophilic solvents and absorption enhancers. Mid-range variants like PEG 1000 form soft, waxy solids tailored for suppository bases, while high-range weights such as PEG 4000 and 6000 solidify into crisp white flakes or powders engineered for tablet compression and nucleic acid precipitation.
Despite these shifting physical states, all grades maintain a stable, near-neutral pH profile between 5.0 and 7.0 alongside complete water solubility.
These structural variations dictate how each polymer matrix behaves on your factory floor and inside your blending vessels. Because liquid grades possess strong hygroscopic properties, chemical blenders widely channel them into topical ointments, daily lotions, and liquid cosmetics as premium humectants.
High-weight solid polymers provide exceptional mechanical lubrication and binding strength, making them industrial staples for PVC extrusion, textile softening, and differential DNA separation in biochemical research laboratories. Grasping these viscosity and melting profiles allows buying teams to coordinate precise material handling, audit raw material suppliers, and protect manufacturing lines from batch-to-batch variation.
Product Packaging
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Applications
Polyethylene glycol is a polymer derived from the hydrolysis of ethylene oxide, which is non-toxic and non irritating, and widely used in various pharmaceutical formulations. Low molecular weight polyethylene glycol has relatively high toxicity, and overall, the toxicity of diols is quite low. Local application of polyethylene glycol, especially mucosal administration, can cause irritating pain. In topical cleansers, this product can increase skin flexibility and has a moisturizing effect similar to glycerin. High doses taken orally may cause diarrhea. In injections, the maximum concentration of polyethylene glycol 300 is about 30% (V/V), and hemolysis can occur at concentrations greater than 40% (V/V).
Melting promoter
An excellent chemical promoter for protoplast fusion. It is a polymer of ethylene glycol with the molecular formula HOCH2 (CH2O · CH2) nCH2OH. It is a white, slightly yellowish waxy solid that is soluble in water and has a slight odor. There are a series of polymers with different relative molecular weights, and those with relative molecular weights between 200 and 6000 can be used as melting promoters, but those with a relative molecular weight of 1000 are better (in liquid form at this time). PEG has strong water solubility. In liquid media, the ether bonds on its molecular surface carry weak negative charges. With the participation of Ca2+ions, positively charged surface proteins or negatively charged glycoproteins can be connected through Ca2+bridges, leading to cell aggregation and fusion. In 50% PEG, the disappearance of free water can lead to cell dehydration, resulting in changes in plasma membrane structure and cell fusion.
The advantages of using PEG in cell fusion are:
① Strong universality, suitable for various cells of animals, plants, and microorganisms.
② It is easier to prepare and control than Sendai virus and other viruses.
③ Stable activity and easy to use.
The disadvantages are:
① The effective concentration range is relatively narrow (50% to 55%), but it is more toxic to cells at this time.
② The fusion process of cells cannot be observed under a microscope.
③ The frequency of inducing hybrid cells is relatively low (about 1 × 10-5).
In addition to being used as a melting promoter, it can also be used to promote yeast uptake of exogenous transformed DNA, and can be used as a precipitant in clinical chemistry, as well as a osmoprotectant for serum and other aqueous solutions or suspensions.
FAQ
The number indicates the average molecular weight. PEG 400 is a liquid used in formulations requiring solubility and permeability enhancement. PEG 1000 is a soft wax, often used as a base in solid dosage forms. PEG 4000 and 6000 are solid flakes or powders used for tablet binding, DNA precipitation, and as an excipient in solid formulations. Higher molecular weight grades generally have higher melting points and lower toxicity.
PEG is a versatile material. In pharmaceuticals, it is used as an excipient, tablet lubricant, and protein-modifying agent. In cosmetics, it serves as a humectant and emulsifier. In industry, it is used as a lubricant, dispersant, and softener. In research, it is essential for DNA precipitation, cell fusion, and nucleic acid hybridization
We supply ≥99% purity across multiple molecular weight grades. Packaging options include: 500g, 1kg, 5kg, and 25kg containers. Custom packaging is available upon request. The material is supplied in sealed containers to prevent moisture uptake.
Store in a sealed container in a cool, dry, well-ventilated area. Protect from moisture, as PEG is hygroscopic. Under proper storage conditions (ambient temperature, sealed), the product remains stable for 12–24 months. Keep away from open flames—PEG is combustible, with flash points of 171–260°C depending on molecular weight.
Why choose Zhishang Bio?
Our logistics desk maintains a constant spot stock buffer exceeding 1,000 metric tons at regional fulfillment hubs. We house pharmaceutical-grade, food-grade, and industrial-grade inventories inside secure packaging configurations, including 25kg liquid drums, 25kg flake bags, and high-density fiber containers.
Small-scale R&D samples (100g to 1kg) clear our loading dock within 24 to 48 hours, while major commercial freight movements (1 MT and above) are palletized and dispatched within 5 to 7 business days.
Build a More Reliable Supply Chain with Zhishang bio
Finding a chemical broker is easy, but finding a factory-direct partner that understands international regulatory compliance, reliable shipping logistics, and batch-to-batch technical transparency is a different game entirely.
Zhishang bio bridges that gap by providing bulk, commercial-scale Polyethylene Glycol with a completely transparent paper trail (MSDS, COA, and regulatory declarations). We invite your technical team to put our material to the test.
Ready to evaluate a sample in your lab or request a direct multi-kilogram/ton-scale price quote? Contact our export specialists at Zhishang bio today, and let’s optimize your raw material pipeline together.
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