PRODUCT
Zhishang Bio Tadalafil CAS 171596-29-5
CAS:171596-29-5 | C22H19N3O4 |MW：389.4 | EINECS NO：687-782-2
Payment: L/C,T/T,D/P,Paypal,Money Gram,Western Union
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Transporta: Ocean, Land,Air, DHL，TNT
Port: Shanghai Port, Qingdao Port
Product Images & Packaging
Describe
Tadalafil, a highly-selective phosphodiesterase-5 inhibitor (PDE-5), is widely used to treat male erectile dysfunction (ED) as well as pulmonary arterial hypertension. Tadalafil is a pharmaceutical material with stable chemical properties. It also has a good bioavailability and long-lasting effects.
Tadalafil has a number of physicochemical characteristics.
Chemical name: (6R, 12aR) -6- (1,3-benzodioxolan-5-yl) -2-methyl-2,3,6,7,12,12a-hexahydropyrazino [1 ‘, 2’: 1,6] pyrido [3,4-b] indole-1,4-dione
Molecular formula: C 22 H 19 N O 4
Weight in grams: 389.41 moles
Tadalafil appears as a powdery white to off-white crystalline powder.
Melting point: approximately 298-300
Tadalafil dissolves easily in organic solvents like DMSO and methanol.
Tadalafil remains stable at room temperatures, but should be kept away from moisture and light, and stored in a dark, dry place.
Tadalafil is used primarily in the pharmaceutical industry to produce tablets.
Tadalafil’s long-lasting effects make it a valuable treatment option. We provide high-purity Tadalafil materials that meet USP/EP standard and are suitable for pharmaceutical manufacturing and research and development. We welcome you to contact us and work together!
| Tadalafil Basic information |
| Product Name: | Tadalafil |
| Synonyms: | TADALAFIL;CIALIS;IC 351;(6R,12AR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1′,2′:1,6]pyrido;GF 196960;ICOS 351;Tildenafil;UK 336017 |
| CAS: | 171596-29-5 |
| MF: | C22H19N3O4 |
| MW: | 389.4 |
| EINECS: | 687-782-2 |
| Brand | China lookchemical |
| Mol File: | 171596-29-5.mol |
| Tadalafil Chemical Properties |
| Melting point | 298-300°C |
| alpha | D20 +71.0° |
| Boiling point | 679.1±55.0 °C(Predicted) |
| density | 1.51±0.1 g/cm3(Predicted) |
| Fp | 2℃ |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| pka | 16.68±0.40(Predicted) |
| color | white to beige |
| optical activity | [α]/D +68 to +78°, c = 1 in chloroform-d |
| BCS Class | 4 |
| Stability: | Unstable in Methanol |
Application
Tadalafil, a long-acting and efficient phosphodiesterase-5 inhibitor, has significant clinical value in the pharmaceutical industry. Pharmaceutical preparations are made primarily from chemical raw materials for the treatment and prevention of diseases such as:
1. Treatment for male erectile dysfunction (ED)
Tadalafil, a first-line treatment for erectile dysfunction (ED), inhibits the PDE-5 enzyme and increases nitric-oxide (NO) mediated vasodilation. It also improves erectile performance by promoting blood flow to the penile cavernosum. Comparatively to similar drugs.
Tadalafil is known as “weekend pills” because it has a long-lasting action. The patient can choose when to take the medication over a longer time period, which improves convenience.
2. Treatment of pulmonary arterial Hypertension (PAH).
Tadalafil has been approved to treat pulmonary arterial hypertension. It does this by inhibiting PDE-5, reducing degradation of cyclic monophosphate and relaxing the smooth muscle of the pulmonary arteries. This reduces pulmonary artery blood pressure and improves the exercise tolerance of the patient.
It is usually taken at low doses over a long period of time.
3. Treatment of symptoms in the lower urinary system related to benign prostate hyperplasia
Tadalafil can also be used to treat symptoms of lower urinary system caused by benign prostate hyperplasia.
Tadalafil’s mechanism of action includes:
Relaxing the smooth muscles of the bladder neck and prostate to improve urine flow
Increase the blood flow in your pelvis, reduce inflammation and fibrosis
Some formulations are approved for patients with ED and BPH. This allows them to achieve “dual effect of one drug”.
4. Additional potential clinical applications
Tadalafil can prevent high-altitude lung edema.
Reynaud’s syndrome: Tadalafil vasodilation may improve peripheral circulation disorders.
Cardiovascular research: explore its potential benefits in heart failure, myocardial ischaemia, and other conditions.
Related References
Pubchem-Tadalafil
Manufacturer of Tadalafil
Achievements
Advantage
Service
FAQ
Advice on Shipping
Achievements
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional Tadalafil manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Advantage
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Service
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.
