Taxifolin CAS 480-18-2 | Dihydroquercetin ≥98%
Taxifolin CAS 480-18-2 Description
Taxifolin (CAS 480-18-2, C ₁₅ H ₁₂ O ₇, MW 304.25), also called dihydroquercetin, is a flavonoid coming from the flavanonol subdivision. It is located normally in larch, Douglas fir, milk thistle, French maritime yearn bark, and onions. The compound appears as a white to yellow crystalline powder with a melting point of 230-233 ° C( dec.) and is soluble in ethanol, methanol, and DMSO.
Structurally, taxifolin is a pentahydroxyflavanone with five hydroxyl groups at the 3-, 3′-, 4′-, 5-, and 7-positions. Unlike quercetin, taxifolin does not have the C2-C3 double bond, which offers it unique chemical residential or commercial properties while preserving solid antioxidant task. The substance has two stereocenters on the C-ring, with the (2R,3 R)- arrangement being one of the most naturally active form.
Product Images & Packaging
Taxifolin Parameters
| Taxifolin Chemical Properties |
| Melting point | 230-233°C (dec.) |
| Boiling point | 365.09°C (rough estimate) |
| density | 1.3326 (rough estimate) |
| refractive index | 1.4790 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.39±0.60(Predicted) |
| color | White to Yellow |
| BRN | 5299277 |
| Major Application | food and beverages |
| Cosmetics Ingredients Functions | ANTIOXIDANT |
| InChI | InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1 |
| InChIKey | CXQWRCVTCMQVQX-LSDHHAIUSA-N |
| SMILES | [C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O |
| LogP | 0.950 |
| CAS DataBase Reference | 480-18-2(CAS DataBase Reference) |
The application of Taxifolin
Cancer Research:
Taxifolin demonstrates anticancer activity through multiple mechanisms. It regulates essential signaling pathways consisting of PI3K/Akt/mTOR, MAPK/ERK, and NF-κB– pathways frequently dysregulated in different cancers cells. It inhibits lump spreading, movement, and invasion, induces G1-phase apprehension and apoptosis, and suppresses angiogenesis by downregulating Hif1-α and VEGF.
Anti-Inflammatory and Antioxidant Research studies:
Research shows taxifolin’s antioxidant task is 3.4 times above quercetin at 100 mg/kg dosages. It efficiently minimizes oxidative stress pens (MDA, protein carbonyls), boosts endogenous antioxidant defenses (GSH, SOD, catalase), and reduces pro-inflammatory conciliators (NF-κB p65, TNF-α, IL-1β) by upregulating Nrf2/HO -1 signaling pathway.
Cardiovascular Research:
Taxifolin protects against acute myocardial injury by triggering the Nrf2/HO -1 pathway and attenuating oxidative cells injury, swelling, and apoptosis. It decreases lotion CK-MB, cardiac troponin I, and LDH levels in anemia models.
Cytoprotective Study:
Researches reveal taxifolin safeguards versus cisplatin-induced nephrotoxicity, testicular damage, and chemotherapy-related poisonings by mitigating oxidative stress and anxiety and apoptosis– making it important for researchers researching chemotherapy-induced negative effects.
Taxifolin 's Procurement Guide
Procurement Guidelines
1. Sample Policy
We can provide a 2-3g free trial package (shipping fee required)
2. Batch procurement
Packaging: 25kg/bag; 220kg/barrel; Special packaging according to your needs
MOQ：1kg
3. Customized services
Concentration customization (90% -99%)
Paeonol’s outsourcing services
FAQ
Taxifolin is the dihydro form of quercetin– it lacks the C2-C3 dual bond. This architectural difference offers taxifolin unique chemical homes. While both are powerful anti-oxidants, taxifolin’s antioxidant activity is about 3.4 times more than quercetin at equivalent dosages. Quercetin has higher bioavailability and even more thoroughly studied, however taxifolin has a more beneficial safety account for long-lasting usage.
We provide ≥ 98% purity (HPLC). Typical packaging sizes include 10mg, 50mg, 100mg, 1g, and 5g. Customized packaging is offered upon demand.
Shop at -20 ° C in a sealed, dry container secured from light. Under correct storage space problems, the product remains stable for up to 2 years. Solutions must be stored at -20 ° C and used within one month.
Yes, taxifolin has actually been thoroughly made use of in preclinical research. It is administrable by mouth and has actually been assessed in computer mouse models for cancer, cardiovascular defense, and chemotherapy-induced poisoning research studies at dosages of 25-50 mg/kg daily. However, note that taxifolin has actually limited bioavailability, so researchers are urged to consider formula methods or advanced medication delivery systems such as nanoformulations or liposomes.
Standard MOQ: 10mg. Stock things ship within 1-2 business days. Bulk orders (5g+) require 5-7 company days processing. Please contact us for particular rates and schedule.
Why Choose zhishangbio as Your Taxifolin Vendor?
Top Quality You Can Rely On
We provide taxifolin with ≥ 98% pureness confirmed by HPLC. Each batch undertakes extensive quality testing covering purity, appearance, melting point, and recognition (NMR). We provide a total Certificate of Analysis (COA) with every delivery, making sure traceability and batch-to-batch uniformity.
Research-Grade Specs
Our taxifolin satisfies high-purity requirements suitable for cell-based assays, in vivo research studies, and logical technique development. The product is supplied in cool kind and is soluble in DMSO and methanol, making it hassle-free for various study applications. Storage space requires -20 ° C in a sealed, light-protected container.
Supply and Adaptable Supply
We maintain supply at our main warehouse. Basic product packaging dimensions vary from 10mg, 50mg, 100mg to gram amounts. Research amounts ship within 1-2 company days. Mass orders and personalized packaging are available upon request. We likewise give full documents including MSDS for safety and security conformity. All products are meant for study use just.
Technical Support
Our group recognizes taxifolin’s application in antioxidant assays, cell society researches, and in vivo designs. We give application referrals and formulation assistance to support your research– whether you are conducting inflammation researches, cancer study, or investigating its synergistic antioxidant ability with various other substances.
Related References
Manufacturer of Taxifolin
Achievements
Advantage
Service
FAQ
Advice on Shipping
Achievements
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional Taxifolin manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Advantage
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Service
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.
