PRODUCT
Description
It is also known as triethoxymethane. The organic compound has a chemical formula of HC (OC2 H 5)VNet or C7 H 16 O3 and a CAS Number of 122-51-0. The molecular structure of triethyl orthoformate is centered on a carbon atom, and three ethoxy group (- OC2 H 5) are connected through three oxygen atoms. It belongs to orthoformate compound. It is classified as an alkylating reagent and a formylation agent.
2. Physical characteristics and morphology
Triethyl orthoformate is a transparent, colorless liquid at room temperature with a pungent smell. Its melting temperature is -76.1 degrees C., its boiling temperature is 145.9 degrees C., it has a relative density of 0.89 (water=1) and a flash point of 30 degrees C. It is only slightly soluble and decomposes slowly when it comes into contact with water. However, this compound is readily soluble in many organic solvents like ethanol and ether. Its relative density of vapor is 5.11 (air=1) and it can diffuse in low places. The compound is highly sensitive to moisture. It should be kept in a closed container and away from fire sources.
3. Background to industry positioning and preparation
Triethyl orthoformate is a fine chemical intermediate that can be produced in the industry by combining sodium ethoxide with chloroform. It can also produced through processes like phase transfer catalysis.
Triethyl orthoformate is a very reactive substance and has a unique position in many fields, including medicine, dyes pesticides and photosensitive materials. It is a key raw material in the production of antimalarials such as quetiapine and chloroquine. It is easy to transport and store under dry conditions. It is also suitable for industrial use.
Product Images & Packaging
Product Parameters
| Triethyl orthoformate Chemical Properties |
| Melting point | -76 °C (lit.) |
| Boiling point | 146 °C (lit.) |
| density | 0.891 g/mL at 25 °C (lit.) |
| vapor density | 5.11 (vs air) |
| vapor pressure | 2.9 mm Hg ( 20 °C) |
| refractive index | n20/D 1.391(lit.) |
| Fp | 86 °F |
| storage temp. | Flammables area |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Liquid |
| color | Clear colorless |
| Water Solubility | 1.35 g/L |
| Sensitive | Moisture Sensitive |
| Merck | 14,6884 |
The application of Triethyl orthoformate
Pharmaceutical industry
Triethyl orthoformate is a synthetic raw material widely used by the pharmaceutical industry. It is used in the production of antimalarials such as quetiapine and chloroquine. This compound is also commonly used in the synthesis for nucleoside antibiotics and antiviral drugs to protect hydroxyl and amino groups. It can help avoid side effects and improve product purity and synthesis efficiency.
The triethyl-orthoformate is a useful alkylating reagent that can be used to introduce ethoxy group or to participate in condensation reactions during the construction of complex drug molecular structures. Many pharmaceutical companies have incorporated it into green synthesis methods due to its mild reaction conditions and ease of handling by-products. This helps improve the environmental and economic friendliness in drug production.
Fine Chemicals and Materials Science
Triethyl orthoformate is an important intermediate in the fine chemical field for the synthesis of various dyes and other photosensitive materials. It is used to prepare cyanine dyes and anti-halo dyes. These dyes are used in many fields, including photosensitive materials for photography, optical recording mediums, and biomarkers. This compound is used as a raw materials for certain photographic drugs and developing sensitizers. Triethyl orthoformate, a chemical intermediate in the pesticide industry is used to synthesize the herbicide Pyriprone. It can be used for preparing materials like high polymers.
Organic Synthesis Reaction
Triethyl orthoformate is an active reagent that is commonly used in organic chemistry laboratories. It has a wide range of applications. It can be used as an alkylating agent to transfer alkyl groups onto various hydroxyl groups in alcohols. This causes alkylation reactions to occur, which generate orthoformate esters. It is possible to produce in situ dialkoxy carbocation under Lewis acid catalysis. This can then be used directly for the formylation of carbonyl ortho-a-carbon, with a simple reaction and high yield. It is also used to protect aldehydes, ketones and ketals.
The Triethyl orthoformate is also capable of participating in classic transformations, such as the Prins reaction or Fischer indole syntheses. This provides key steps in the construction of heterocyclic compounds.
Triethyl orthoformate is a fine chemical intermediate that embodies all the benefits of fine chemicals. This is not only a cornerstone in the pharmaceutical industry for the synthesis of antimalarials and antibiotics but it’s also a raw material used to prepare cyanine dyes as well as photosensitive materials. It is an essential reagent for alkylation and formylation in organic synthesis.
Due to its unique reactivity, this multifunctional compound is important in a wide range of applications from laboratory research to production.
Triethyl orthoformate 's Procurement Guide
Procurement Guidelines
1. Sample Policy
We can provide a 2-3g free trial package (shipping fee required)
2. Batch procurement
Packaging: 25kg/bag; 220kg/barrel; Special packaging according to your needs
MOQ：1kg
3. Customized services
Concentration customization (90% -99%)
Paeonol’s outsourcing services
FAQ
Mainly used as aldehyde ketone carbonyl protectants, formylation reagents, and raw materials for acetalization reactions, it is widely used in the synthesis of pyrimidine, pyrazole heterocyclic drugs, antiviral drugs, antibiotics, and high-end pesticide intermediates. It is an essential acid ester reagent for pharmaceutical synthesis.
It is prone to slow hydrolysis when in contact with water, and acid and alkali will accelerate decomposition. It must be strictly sealed, isolated from moisture, and stored in a cool, dry, and dark place. It is strictly prohibited to mix it with water, acid, or alkali. It is recommended to store it under nitrogen for long-term protection.
Conventional GC purity ≥ 99.0%; Belonging to Class 3 flammable liquid (UN2524), with a closed flash point of 30 ℃, it is shipped and transported by sea and land according to the regulations for flammable organic solvents, and has a complete compliance dangerous goods package certificate.
Related References
Manufacturer of Triethyl orthoformate
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional Triethyl orthoformate manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
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1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
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