High-Purity Retinoic Acid CAS 302-79-4 | RAR Agonist for Research
Retinoic acid CAS 302-79-4
CAS:302-79-4 | C20H28O2 |MW：300.44 | EINECS NO：206-129-0
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Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Transporta: Ocean, Land,Air, DHL，TNT
Port: Shanghai Port, Qingdao Port
Description
Retinoic acid (CAS 302-79-4, C₂₀H₂₈O₂, MW 300.44), also known as ATRA, Tretinoin, or Vitamin A acid, is a naturally occurring metabolite of vitamin A (retinol) . It plays an essential role in regulating cell growth, differentiation, and organogenesis . The compound appears as a yellow crystalline powder with a melting point of 180-182°C .
Mechanistically, retinoic acid functions as a natural agonist of retinoic acid nuclear receptors (RARα/β/γ) with an IC₅₀ of 14 nM . It also binds to PPARβ/δ with a Kd of 17 nM . Through RAR/RXR receptor binding, ATRA modulates gene transcription that controls cellular differentiation and proliferation pathways, making it a critical research tool for developmental biology and oncology studies . For cell culture applications, it primes embryonic stem cells to differentiate into neurons and other lineages .
Key Applications
Stem Cell and Developmental Biology Research:
Used to differentiate embryonic stem cells into motor neurons, Xenopus ectoderm into pancreas, and study neural differentiation . Also used in organoid culture protocols.
Cancer Research:
Clinically, ATRA is approved for acute promyelocytic leukemia (APL) treatment . It induces terminal differentiation in human promyelocytic leukemia cells at concentrations as low as 1 nM . Studied for chemopreventive and antineoplastic activities in other cancers .
Cellular and Molecular Biology:
Used to study retinoid signaling, epigenetic regulation by RARα, and spermatogonial differentiation . Also inhibits proliferation and stimulates tyrosinase activity in melanoma cell lines .
Biochemical Research:
Serves as a reference standard for HPLC and LC-MS method validation. Also used in anti-aging and dermatological research .
Storage and Handling
Retinoic acid is light-sensitive and air-sensitive. Store powder at -20°C in a sealed, dry container under inert atmosphere, protected from light . DMSO stock solutions should be stored at -20°C and used within 1 month .
Product Images & Packaging
Product Parameters
| Retinoic acid Chemical Properties |
| Melting point | 180-181 °C (lit.) |
| Boiling point | 381.66°C (rough estimate) |
| density | 1.0597 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | -20°C |
| solubility | Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent). |
| pka | 4.73±0.33(Predicted) |
| form | powder |
| color | yellow |
| biological source | synthetic (organic) |
| Water Solubility | insoluble |
| Sensitive | Light Sensitive |
| Merck | 14,8165 |
| BRN | 2057223 |
Why Source Retinoic Acid from zhishangbio?
Quality You Can Rely On
We supply retinoic acid with ≥98% purity verified by HPLC . Each batch undergoes rigorous quality testing covering appearance (yellow powder), assay, and solubility. For specialized applications, cell-culture tested grades and higher purity (99.5%) are available . A complete Certificate of Analysis (COA) accompanies every shipment, ensuring traceability and batch-to-batch consistency for your critical research.
Inventory and Supply Chain
We maintain stock at our central warehouse. Standard packaging includes 100mg, 500mg, 1g, and bulk sizes . Research quantities ship within 1-2 business days. Bulk orders require 5-7 business days processing. Products are stored at -20°C in light-protected, inert atmosphere packaging to maintain stability. Under recommended storage, the product remains stable for 24 months .
Technical Support
Our technical team provides guidance for retinoic acid in stem cell differentiation, cancer research, and developmental biology applications. Complete documentation including COA and MSDS accompanies every shipment. Custom packaging and larger quantities are available upon request.
Retinoic acid's Procurement Guide
Procurement Guidelines
1. Sample Policy
We can provide a 2-3g free trial package (shipping fee required)
2. Batch procurement
Packaging: 25kg/bag; 220kg/barrel; Special packaging according to your needs
MOQ：1kg
3. Customized services
Concentration customization (90% -99%)
Paeonol’s outsourcing services
FAQ
They are the same compound. Retinoic acid, ATRA (all-trans-retinoic acid), and Tretinoin all refer to CAS 302-79-4 . Tretinoin is the INN name used in pharmaceutical contexts, while ATRA distinguishes the all-trans isomer from other retinoic acid isomers.
For inducing morphological and functional terminal differentiation in promyelocytic leukemia cells, concentrations from 1 nM (minimal) to 1 µM (maximal) are effective . For neuronal differentiation of embryonic stem cells, typical working concentrations range from 0.1 to 1 µM. Optimal concentration should be determined empirically for your specific cell line.
Store powder at -20°C in a sealed, dry container under inert atmosphere, protected from light . DMSO stock solutions should be stored at -20°C and used within one month . Avoid repeated freeze-thaw cycles.
Retinoic acid is classified as a reproductive toxin (Category 1B), and is harmful if swallowed and causes skin/eye irritation . Use appropriate PPE (gloves, safety goggles, lab coat) and handle in a fume hood. Avoid release to the environment due to aquatic toxicity .
Related References
Manufacturer of Retinoic acid
Achievements
Advantage
Service
FAQ
Advice on Shipping
Achievements
Zhishang Bio is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of cosmetic raw materials, disinfectants, flavors and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Zhishang Bio will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional Retinoic acid manufacturer, Zhi shang Bio has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Advantage
Zhishang Bio is a professional enterprise engaged in the research and development, production, and sales of chemical raw materials. It has a strong supply chain system and strict quality control standards to ensure the provision of high-quality products with high purity and stability to customers.
Zhishang Bio’s core strength is its independent research and design capabilities. It has advanced production equipment, testing laboratories and can customize chemical raw materials to meet the market demands. This includes pharmaceuticals, electronic, coatings and agricultural applications.
Zhishang Bio’s supply chain management is based on long-term relationships with domestic and international suppliers of high quality to guarantee a stable supply, optimize logistic systems, and achieve efficient distribution. This helps reduce the cost of customer purchases.
We adhere to international environmental standards and we also adhere to the concept that environmental protection and safety production are important. All production processes must comply with these standards in order to guarantee that our products will be green and sustainable.
With a professional technical team and comprehensive after-sales service, Zhishang Bio can provide customers with precise technical support, solve application problems, and help customers enhance product competitiveness.
We are always customer-oriented and committed to becoming a trusted chemical raw material partner.
Service
Zhishang Biography is dedicated to using clients extensive and expert service, including chemical raw material. The customers will certainly receive hassle-free, efficient and one-stop options.
1. Custom-made Supply Solutions
Zhishang Bio provides tailored services for clients in the chemical basic material sector, including special bit dimension, solvent residue control, stability optimizations and more. Clients can personalize their services to satisfy details requirements in industries such as drugs, electronic devices, and finishings.
2. Strict quality assurance
Zhishang Bio utilizes advanced screening equipment and stringent quality examination procedures, in addition to various other files, to guarantee that every batch of products is certified with international criteria such ISO GMP, REACH, and so on. Customers are also given with full quality records and conformity documents.
The supply chain is secure
Zhishang Bio has actually established lasting calculated collaborations with worldwide makers of top notch raw materials to make certain a secure supply, maximize the storage facility and logistics system, and assistance both small-scale examinations and large orders. It adjusted to the changing requirements of clients by responding flexibly to these changes.
4. Technical support
Zhishang Bio’s technical group can offer suggestions on product applications, formula optimization and analysis of industry patterns to aid clients fix technological troubles during production and boost item efficiency.
5. Efficient after-sales service
Zhishang Bio provides complete monitoring, reacts to client requests and delivers promptly. This will certainly make certain customer complete satisfaction.
Zhishang Biography intends to help consumers expand their service by providing the very best solutions and chemical resources.
FAQ
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
Zhishang Bio company in China that exports chemicals, Cosmetic raw materials, and Intermediates for over 70 countries now.
And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.
The company integrates research and development, production, and trade, with a modern production base, advanced testing equipment, and an experienced technical team to ensure that products reach industry-leading levels in purity, stability, and environmental friendliness.
